Chaperone-related immune dysfunction: An emergent property of distorted chaperone networks

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Abstract

Molecular chaperones (heat shock proteins) are important components of cellular networks, such as protein-protein and gene regulatory networks. Chaperones participate in the folding of immunologically important proteins, presentation of antigens and activation of the immune system. Here, we propose that chaperone-related immune dysfunction might be more general than was previously thought. Mutations and polymorphism of chaperones and the regulators of their synthesis, heat shock factor-1, chaperone diseases, sick chaperones and chaperone overload might all affect (mostly impairing) immune responses.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
JournalTrends in Immunology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2006

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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