Changing world of neutrophils

Csaba I. Timár, Ákos M. Lorincz, E. Ligeti

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Neutrophilic granulocytes are no longer regarded as cells involved only in the last phase of the immune response with one single - although vitally important - task: engulfing and killing of microorganisms marked by immunoglobulin or complement fragments. In recent years, it was shown that neutrophils are actively involved in initiation and organization of the adaptive immune response by releasing various cytokines, interacting with all major types of immune cells, regulating their own lifespan, and participating in the anaphylactic reaction and in several classically nonimmune functions such as hemostasis, atherogenesis, and even insulin resistance. The antibacterial effect is no longer restricted to killing and destruction of microorganisms sequestered in the phagosomal space. Bacteriostasis also occurs at certain locations of the extracellular space, by formation of neutrophil extracellular traps (NETs) that were shown in the last 2 years to have a significant role in the prevention of dissemination of microorganisms. Extracellular vesicles represent a recently discovered form of intercellular communication carried out both by lipids, proteins, and nucleic acids. In this review, we also summarize the role of neutrophil-derived extracellular vesicles in modifying the function of other cell types as well as their direct antibacterial effect that differs significantly from mechanisms applied either by neutrophils or by the NETs.

Original languageEnglish
Pages (from-to)1521-1533
Number of pages13
JournalPflugers Archiv European Journal of Physiology
Volume465
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Microorganisms
Neutrophils
Extracellular Space
Adaptive Immunity
Anaphylaxis
Hemostasis
Granulocytes
Nucleic Acids
Insulin Resistance
Immunoglobulins
Atherosclerosis
Insulin
Cytokines
Lipids
Communication
Proteins
Extracellular Traps
Extracellular Vesicles

Keywords

  • Antibacterial effect
  • Ectosomes
  • Extracellular vesicles
  • Microvesicles
  • Neutrophil extracellular traps (NETs)
  • Neutrophils

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Changing world of neutrophils. / Timár, Csaba I.; Lorincz, Ákos M.; Ligeti, E.

In: Pflugers Archiv European Journal of Physiology, Vol. 465, No. 11, 11.2013, p. 1521-1533.

Research output: Contribution to journalArticle

Timár, Csaba I. ; Lorincz, Ákos M. ; Ligeti, E. / Changing world of neutrophils. In: Pflugers Archiv European Journal of Physiology. 2013 ; Vol. 465, No. 11. pp. 1521-1533.
@article{70eea18fbcde400bad20e43d42ce2351,
title = "Changing world of neutrophils",
abstract = "Neutrophilic granulocytes are no longer regarded as cells involved only in the last phase of the immune response with one single - although vitally important - task: engulfing and killing of microorganisms marked by immunoglobulin or complement fragments. In recent years, it was shown that neutrophils are actively involved in initiation and organization of the adaptive immune response by releasing various cytokines, interacting with all major types of immune cells, regulating their own lifespan, and participating in the anaphylactic reaction and in several classically nonimmune functions such as hemostasis, atherogenesis, and even insulin resistance. The antibacterial effect is no longer restricted to killing and destruction of microorganisms sequestered in the phagosomal space. Bacteriostasis also occurs at certain locations of the extracellular space, by formation of neutrophil extracellular traps (NETs) that were shown in the last 2 years to have a significant role in the prevention of dissemination of microorganisms. Extracellular vesicles represent a recently discovered form of intercellular communication carried out both by lipids, proteins, and nucleic acids. In this review, we also summarize the role of neutrophil-derived extracellular vesicles in modifying the function of other cell types as well as their direct antibacterial effect that differs significantly from mechanisms applied either by neutrophils or by the NETs.",
keywords = "Antibacterial effect, Ectosomes, Extracellular vesicles, Microvesicles, Neutrophil extracellular traps (NETs), Neutrophils",
author = "Tim{\'a}r, {Csaba I.} and Lorincz, {{\'A}kos M.} and E. Ligeti",
year = "2013",
month = "11",
doi = "10.1007/s00424-013-1285-1",
language = "English",
volume = "465",
pages = "1521--1533",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Changing world of neutrophils

AU - Timár, Csaba I.

AU - Lorincz, Ákos M.

AU - Ligeti, E.

PY - 2013/11

Y1 - 2013/11

N2 - Neutrophilic granulocytes are no longer regarded as cells involved only in the last phase of the immune response with one single - although vitally important - task: engulfing and killing of microorganisms marked by immunoglobulin or complement fragments. In recent years, it was shown that neutrophils are actively involved in initiation and organization of the adaptive immune response by releasing various cytokines, interacting with all major types of immune cells, regulating their own lifespan, and participating in the anaphylactic reaction and in several classically nonimmune functions such as hemostasis, atherogenesis, and even insulin resistance. The antibacterial effect is no longer restricted to killing and destruction of microorganisms sequestered in the phagosomal space. Bacteriostasis also occurs at certain locations of the extracellular space, by formation of neutrophil extracellular traps (NETs) that were shown in the last 2 years to have a significant role in the prevention of dissemination of microorganisms. Extracellular vesicles represent a recently discovered form of intercellular communication carried out both by lipids, proteins, and nucleic acids. In this review, we also summarize the role of neutrophil-derived extracellular vesicles in modifying the function of other cell types as well as their direct antibacterial effect that differs significantly from mechanisms applied either by neutrophils or by the NETs.

AB - Neutrophilic granulocytes are no longer regarded as cells involved only in the last phase of the immune response with one single - although vitally important - task: engulfing and killing of microorganisms marked by immunoglobulin or complement fragments. In recent years, it was shown that neutrophils are actively involved in initiation and organization of the adaptive immune response by releasing various cytokines, interacting with all major types of immune cells, regulating their own lifespan, and participating in the anaphylactic reaction and in several classically nonimmune functions such as hemostasis, atherogenesis, and even insulin resistance. The antibacterial effect is no longer restricted to killing and destruction of microorganisms sequestered in the phagosomal space. Bacteriostasis also occurs at certain locations of the extracellular space, by formation of neutrophil extracellular traps (NETs) that were shown in the last 2 years to have a significant role in the prevention of dissemination of microorganisms. Extracellular vesicles represent a recently discovered form of intercellular communication carried out both by lipids, proteins, and nucleic acids. In this review, we also summarize the role of neutrophil-derived extracellular vesicles in modifying the function of other cell types as well as their direct antibacterial effect that differs significantly from mechanisms applied either by neutrophils or by the NETs.

KW - Antibacterial effect

KW - Ectosomes

KW - Extracellular vesicles

KW - Microvesicles

KW - Neutrophil extracellular traps (NETs)

KW - Neutrophils

UR - http://www.scopus.com/inward/record.url?scp=84887198359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887198359&partnerID=8YFLogxK

U2 - 10.1007/s00424-013-1285-1

DO - 10.1007/s00424-013-1285-1

M3 - Article

VL - 465

SP - 1521

EP - 1533

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 11

ER -