A különbözo neuropeptidtartalmú idegelemek számának változása humán gyulladt epehólyagban

Translated title of the contribution: Changes of the different neuropeptide containing nerve elements in the inflamed human gallbladder

Éva Pongor, E. Fehér, András Lászik, Péter Sipos

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background, aims: The changes of different neuropeptide containing nerve elements might play a role in the pathogenesis of cholecystitis and the formation of gallstones, therefore the authors have investigated the density of the neuropeptide containing nerve fibres and immunocompetent cells in human gallbladder (control and cholecystitis). Methods: The different neuropeptide containing nerve elements and immunocytes were detected by avidin-biotin-peroxidase (ABC) immunohistochemistry. Results: In the control gallbladder the density of the different neuropeptide containing nerve fibres showed different pattern in all layers. In the inflamed gall-bladder the number of the vasoactive intestinal polypeptide (VIP) positive nerve fibres increased significantly, very dense immunoreactive (IR) nerve fibres were located mainly in the tunica mucosa just below the epithelial lining. The number of the VIP IR nerve cell bodies was also increased. However, the number of the substance P (SP) IR nerve fibres was decreased significantly in the cholecystitis. The number of the neuropeptide Y (NPY) nerve fibres showed no changes, while their distribution was altered compared to the control. In the inflammed area the number of immunocompetent cells was strongly increased (being granulocytes, lymphocytes, plasma cells and mast cells) and some of them were also immunoreactive for SP, calcitonin gene-related peptide (CGRP) and VIP. Close contacts were detected between IR nerve fibres and the immunocytes in several cases. Conclusions: During inflammation the changes of the neuropeptide containing nerve fibres might alter the function (causing dilation) of the gall bladder, the activated immunocytes can also synthesize neuropeptides (SP, CGRP, VIP), so the released materials (cytokines, chemokines, histamine, as well as neuropeptides) might act in an autocrine and/or paracrine way influencing the function of the organ and of the immune system.

Original languageHungarian
Pages (from-to)1513-1518
Number of pages6
JournalOrvosi Hetilap
Volume147
Issue number32
Publication statusPublished - Aug 13 2006

Fingerprint

Gallbladder
Neuropeptides
Nerve Fibers
Vasoactive Intestinal Peptide
Cholecystitis
Substance P
Calcitonin Gene-Related Peptide
Urinary Bladder
Avidin
Neuropeptide Y
Gallstones
Biotin
Plasma Cells
Chemokines
Granulocytes
Mast Cells
Histamine
Peroxidase
Dilatation
Immune System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A különbözo neuropeptidtartalmú idegelemek számának változása humán gyulladt epehólyagban. / Pongor, Éva; Fehér, E.; Lászik, András; Sipos, Péter.

In: Orvosi Hetilap, Vol. 147, No. 32, 13.08.2006, p. 1513-1518.

Research output: Contribution to journalArticle

Pongor, Éva ; Fehér, E. ; Lászik, András ; Sipos, Péter. / A különbözo neuropeptidtartalmú idegelemek számának változása humán gyulladt epehólyagban. In: Orvosi Hetilap. 2006 ; Vol. 147, No. 32. pp. 1513-1518.
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abstract = "Background, aims: The changes of different neuropeptide containing nerve elements might play a role in the pathogenesis of cholecystitis and the formation of gallstones, therefore the authors have investigated the density of the neuropeptide containing nerve fibres and immunocompetent cells in human gallbladder (control and cholecystitis). Methods: The different neuropeptide containing nerve elements and immunocytes were detected by avidin-biotin-peroxidase (ABC) immunohistochemistry. Results: In the control gallbladder the density of the different neuropeptide containing nerve fibres showed different pattern in all layers. In the inflamed gall-bladder the number of the vasoactive intestinal polypeptide (VIP) positive nerve fibres increased significantly, very dense immunoreactive (IR) nerve fibres were located mainly in the tunica mucosa just below the epithelial lining. The number of the VIP IR nerve cell bodies was also increased. However, the number of the substance P (SP) IR nerve fibres was decreased significantly in the cholecystitis. The number of the neuropeptide Y (NPY) nerve fibres showed no changes, while their distribution was altered compared to the control. In the inflammed area the number of immunocompetent cells was strongly increased (being granulocytes, lymphocytes, plasma cells and mast cells) and some of them were also immunoreactive for SP, calcitonin gene-related peptide (CGRP) and VIP. Close contacts were detected between IR nerve fibres and the immunocytes in several cases. Conclusions: During inflammation the changes of the neuropeptide containing nerve fibres might alter the function (causing dilation) of the gall bladder, the activated immunocytes can also synthesize neuropeptides (SP, CGRP, VIP), so the released materials (cytokines, chemokines, histamine, as well as neuropeptides) might act in an autocrine and/or paracrine way influencing the function of the organ and of the immune system.",
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AU - Pongor, Éva

AU - Fehér, E.

AU - Lászik, András

AU - Sipos, Péter

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AB - Background, aims: The changes of different neuropeptide containing nerve elements might play a role in the pathogenesis of cholecystitis and the formation of gallstones, therefore the authors have investigated the density of the neuropeptide containing nerve fibres and immunocompetent cells in human gallbladder (control and cholecystitis). Methods: The different neuropeptide containing nerve elements and immunocytes were detected by avidin-biotin-peroxidase (ABC) immunohistochemistry. Results: In the control gallbladder the density of the different neuropeptide containing nerve fibres showed different pattern in all layers. In the inflamed gall-bladder the number of the vasoactive intestinal polypeptide (VIP) positive nerve fibres increased significantly, very dense immunoreactive (IR) nerve fibres were located mainly in the tunica mucosa just below the epithelial lining. The number of the VIP IR nerve cell bodies was also increased. However, the number of the substance P (SP) IR nerve fibres was decreased significantly in the cholecystitis. The number of the neuropeptide Y (NPY) nerve fibres showed no changes, while their distribution was altered compared to the control. In the inflammed area the number of immunocompetent cells was strongly increased (being granulocytes, lymphocytes, plasma cells and mast cells) and some of them were also immunoreactive for SP, calcitonin gene-related peptide (CGRP) and VIP. Close contacts were detected between IR nerve fibres and the immunocytes in several cases. Conclusions: During inflammation the changes of the neuropeptide containing nerve fibres might alter the function (causing dilation) of the gall bladder, the activated immunocytes can also synthesize neuropeptides (SP, CGRP, VIP), so the released materials (cytokines, chemokines, histamine, as well as neuropeptides) might act in an autocrine and/or paracrine way influencing the function of the organ and of the immune system.

KW - Cholecystitis

KW - Immunoreactive

KW - Innervation

KW - Neuroimmuno-modulation

KW - Neuropeptides

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