Changes of serum carotenoids in patients with esophageal, gastric, hepatocellular, pancreatic and colorectal cancer

György Rumi, Z. Matus, G. Tóth, A. Pár, Zsuzsanna Nagy, A. Vincze, G. Rumi, G. Mózsik

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Abstract

The serum levels of carotenoids (vitamin A, lutein, zeaxanthin, alfa- and beta cryptoxanthin, alfa- and beta-carotene) were measured in healthy persons (n = 40) and in 98 patients with different malignant gastrointestinal diseases (44 patients with colon adenocarcinoma, 21 with gastric cancer, 15 with hepatocellular adenocarcinoma, 10 patients with pancreas adenocarcinoma and eight patients with esophagus cancer). The serum levels of carotenoids were measured with high-pressure liquid chromatography. The sera of the patients were taken at the time of the diagnosis. Results: the measurements indicated that (1) the serum level of vitamin A and zeaxanthin were significantly lower in all of these groups (except of pancreas adenocarcinoma), but the extent of the Adecrease was different in the patients with different types of gastrointestinal malignancy. The serum level of vitamin A was in the healthy subjects 2.072±0.332 mmol/l and in the case of gastrointestinal malignancies was 0.77±0.14 mmol/l (P <0.001) The serum level of zeaxanthin was in the healthy subjects 0.143±0.057 mmol/l and at the malignancies was 0.042±0.014 mmol/l (P <0.01). (2) There were no significant differences in the serum levels of other carotenoids in the checked groups. (3) The serum level of cholesterol, total protein, albumin and haemoglobin were in the normal range in these patients. These results indicate that the carotenoids may be responsible nutritional factors (as nutritional scavengers) in the development of different malignant diseases. This supposed role in the carcinogenesis does not depend fully on the vitamin A activity.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - 2001

Fingerprint

Carotenoids
Liver Neoplasms
Esophageal Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Colorectal Neoplasms
Serum
Vitamin A
Adenocarcinoma
Pancreas
Healthy Volunteers
Lutein
Neoplasms
Gastrointestinal Diseases
beta Carotene
Albumins
Colon
Carcinogenesis
Reference Values
Hemoglobins

Keywords

  • Carotenoids
  • Malignant gastrointestinal diseases
  • Vitamin A

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

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title = "Changes of serum carotenoids in patients with esophageal, gastric, hepatocellular, pancreatic and colorectal cancer",
abstract = "The serum levels of carotenoids (vitamin A, lutein, zeaxanthin, alfa- and beta cryptoxanthin, alfa- and beta-carotene) were measured in healthy persons (n = 40) and in 98 patients with different malignant gastrointestinal diseases (44 patients with colon adenocarcinoma, 21 with gastric cancer, 15 with hepatocellular adenocarcinoma, 10 patients with pancreas adenocarcinoma and eight patients with esophagus cancer). The serum levels of carotenoids were measured with high-pressure liquid chromatography. The sera of the patients were taken at the time of the diagnosis. Results: the measurements indicated that (1) the serum level of vitamin A and zeaxanthin were significantly lower in all of these groups (except of pancreas adenocarcinoma), but the extent of the Adecrease was different in the patients with different types of gastrointestinal malignancy. The serum level of vitamin A was in the healthy subjects 2.072±0.332 mmol/l and in the case of gastrointestinal malignancies was 0.77±0.14 mmol/l (P <0.001) The serum level of zeaxanthin was in the healthy subjects 0.143±0.057 mmol/l and at the malignancies was 0.042±0.014 mmol/l (P <0.01). (2) There were no significant differences in the serum levels of other carotenoids in the checked groups. (3) The serum level of cholesterol, total protein, albumin and haemoglobin were in the normal range in these patients. These results indicate that the carotenoids may be responsible nutritional factors (as nutritional scavengers) in the development of different malignant diseases. This supposed role in the carcinogenesis does not depend fully on the vitamin A activity.",
keywords = "Carotenoids, Malignant gastrointestinal diseases, Vitamin A",
author = "Gy{\"o}rgy Rumi and Z. Matus and G. T{\'o}th and A. P{\'a}r and Zsuzsanna Nagy and A. Vincze and G. Rumi and G. M{\'o}zsik",
year = "2001",
doi = "10.1016/S0928-4257(01)00031-6",
language = "English",
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TY - JOUR

T1 - Changes of serum carotenoids in patients with esophageal, gastric, hepatocellular, pancreatic and colorectal cancer

AU - Rumi, György

AU - Matus, Z.

AU - Tóth, G.

AU - Pár, A.

AU - Nagy, Zsuzsanna

AU - Vincze, A.

AU - Rumi, G.

AU - Mózsik, G.

PY - 2001

Y1 - 2001

N2 - The serum levels of carotenoids (vitamin A, lutein, zeaxanthin, alfa- and beta cryptoxanthin, alfa- and beta-carotene) were measured in healthy persons (n = 40) and in 98 patients with different malignant gastrointestinal diseases (44 patients with colon adenocarcinoma, 21 with gastric cancer, 15 with hepatocellular adenocarcinoma, 10 patients with pancreas adenocarcinoma and eight patients with esophagus cancer). The serum levels of carotenoids were measured with high-pressure liquid chromatography. The sera of the patients were taken at the time of the diagnosis. Results: the measurements indicated that (1) the serum level of vitamin A and zeaxanthin were significantly lower in all of these groups (except of pancreas adenocarcinoma), but the extent of the Adecrease was different in the patients with different types of gastrointestinal malignancy. The serum level of vitamin A was in the healthy subjects 2.072±0.332 mmol/l and in the case of gastrointestinal malignancies was 0.77±0.14 mmol/l (P <0.001) The serum level of zeaxanthin was in the healthy subjects 0.143±0.057 mmol/l and at the malignancies was 0.042±0.014 mmol/l (P <0.01). (2) There were no significant differences in the serum levels of other carotenoids in the checked groups. (3) The serum level of cholesterol, total protein, albumin and haemoglobin were in the normal range in these patients. These results indicate that the carotenoids may be responsible nutritional factors (as nutritional scavengers) in the development of different malignant diseases. This supposed role in the carcinogenesis does not depend fully on the vitamin A activity.

AB - The serum levels of carotenoids (vitamin A, lutein, zeaxanthin, alfa- and beta cryptoxanthin, alfa- and beta-carotene) were measured in healthy persons (n = 40) and in 98 patients with different malignant gastrointestinal diseases (44 patients with colon adenocarcinoma, 21 with gastric cancer, 15 with hepatocellular adenocarcinoma, 10 patients with pancreas adenocarcinoma and eight patients with esophagus cancer). The serum levels of carotenoids were measured with high-pressure liquid chromatography. The sera of the patients were taken at the time of the diagnosis. Results: the measurements indicated that (1) the serum level of vitamin A and zeaxanthin were significantly lower in all of these groups (except of pancreas adenocarcinoma), but the extent of the Adecrease was different in the patients with different types of gastrointestinal malignancy. The serum level of vitamin A was in the healthy subjects 2.072±0.332 mmol/l and in the case of gastrointestinal malignancies was 0.77±0.14 mmol/l (P <0.001) The serum level of zeaxanthin was in the healthy subjects 0.143±0.057 mmol/l and at the malignancies was 0.042±0.014 mmol/l (P <0.01). (2) There were no significant differences in the serum levels of other carotenoids in the checked groups. (3) The serum level of cholesterol, total protein, albumin and haemoglobin were in the normal range in these patients. These results indicate that the carotenoids may be responsible nutritional factors (as nutritional scavengers) in the development of different malignant diseases. This supposed role in the carcinogenesis does not depend fully on the vitamin A activity.

KW - Carotenoids

KW - Malignant gastrointestinal diseases

KW - Vitamin A

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JO - Journal de Physiologie

JF - Journal de Physiologie

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