Changes of protein glycosylation in the course of radiotherapy

Eszter Tóth, Károly Vékey, Olivér Ozohanics, Anita Jeko, Iwona Dominczyk, Piotr Widlak, László Drahos

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This is the first study of changes in protein glycosylation due to exposure of human subjects to ionizing radiation. Site specific glycosylation patterns of 7 major plasma proteins were analyzed; 171 glycoforms were identified; and the abundance of 99 of these was followed in the course of cancer radiotherapy in 10 individual patients. It was found that glycosylation of plasma proteins does change in response to partial body irradiation (~60. Gy), and the effects last during follow-up; the abundance of some glycoforms changed more than twofold. Both the degree of changes and their time-evolution showed large inter-individual variability.

Original languageEnglish
Pages (from-to)380-386
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume118
DOIs
Publication statusPublished - Jan 25 2016

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Keywords

  • Glycosylation
  • Glycosylation pattern
  • Head and neck cancer
  • Proteomics
  • Radiotherapy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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