Changes of porous poly(ε-caprolactone) bone grafts resulted from e-beam sterilization process

L. Oláh, K. Filipczak, T. Czvikovszky, T. Czigány, L. Borbás

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The most important mechanical feature of poly(ε-caprolactone) (PCL) foams applied in bone tissue engineering as a scaffold, has been investigated as a function of irradiation dose. Radiation is proposed for the sterilization of the polymer before the implantation. Polycaprolactone scaffold foams were obtained by combination of compression molding and particulate leaching techniques. The porogen was changed in the range 74-96 w% and the irradiation dose was varied from 25 to 150 kGy. Our results show that yield strength is not a function of radiation dose, but is rather influenced by the porosity, while the critical strain is mainly dependent on the dose. All these together mean that the modulus of the elasticity of PCL foams is dependent on both the porosity and the dose.

Original languageEnglish
Pages (from-to)1430-1434
Number of pages5
JournalRadiation Physics and Chemistry
Volume76
Issue number8-9
DOIs
Publication statusPublished - Aug 2007

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bones
dosage
foams
porosity
irradiation
tissue engineering
radiation
leaching
yield strength
particulates
implantation
elastic properties
polymers

Keywords

  • Biomaterials
  • Bone implants
  • Macroporous polymers
  • Mechanical properties
  • Poly-caprolactone
  • Scaffold

ASJC Scopus subject areas

  • Radiation

Cite this

Changes of porous poly(ε-caprolactone) bone grafts resulted from e-beam sterilization process. / Oláh, L.; Filipczak, K.; Czvikovszky, T.; Czigány, T.; Borbás, L.

In: Radiation Physics and Chemistry, Vol. 76, No. 8-9, 08.2007, p. 1430-1434.

Research output: Contribution to journalArticle

Oláh, L. ; Filipczak, K. ; Czvikovszky, T. ; Czigány, T. ; Borbás, L. / Changes of porous poly(ε-caprolactone) bone grafts resulted from e-beam sterilization process. In: Radiation Physics and Chemistry. 2007 ; Vol. 76, No. 8-9. pp. 1430-1434.
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