Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: To determine the plasma carnitine ester profile in adult patients with ulcerative culitis (UC) and compared with healthy control subjects. Method: Using ESI triple quadrupole tandem mass spectrometry, the carnitine ester profile was measured in 44 patients with UC and 44 age- and sex-matched healthy controls. Results: There was no significant difference in the fasting free carnitine level between the patients with UC and the healthy controls. The fasting propionyl-(0.331 ± 0.019 vs 0.392 ± 0.017 μmol/L), butyryl-(0.219 ± 0.014 vs 0.265 ± 0.012), and isovalerylcarnitine (0.111 ± 0.008 vs 0.134 ± 0.008) levels were decreased in the UC patients. By contrast, the level of octanoyl- (0.147 ± 0.009 vs 0.114 ± 0.008), decanoyl- (0.180 ± 0.012 vs 0.137 ± 0.008), myristoyl-(0.048 ± 0.003 vs 0.039 ± 0.003), palmitoyl- (0.128 ± 0.006 vs 0.109 ± 0.004), palmitoleyl- (0.042 ± 0.003 vs 0.031 ± 0.002) and oleylcarnitine (0.183 ± 0.007 vs 0.163 ± 0.007; P < 0.05 in all comparisons) were increased in the patients with UC. Conclusion: Our data suggest selective involvement of the carnitine esters in UC patients, probably due to their altered metabolism.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalWorld journal of gastroenterology
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 7 2006

Keywords

  • Carnitine
  • Carnitine ester profile
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Changes of plasma fasting carnitine ester profile in patients with ulcerative colitis'. Together they form a unique fingerprint.

  • Cite this