The aim of this work was to study the magnesium content in the placenta and body fluid samples in healthy pregnant and preeclamptic patients. Magnesium content in the placenta and in body fluid samples (maternal venous blood serum, umbilical cord blood serum, amniotic fluid) of healthy pregnant patients (n=126) and of those with preeclampsia (mild n=23, severe n=30) was measured by atomic absorption spectrophotometry. The serum magnesium content significantly (p < 0.001, p < 0.05) decreases in severe preeclampsia compared to the nonpregnant (n=65) and healthy pregnant state. In severe preeclampsia the placenta! magnesium content was significantly (p < 0.05) lower at the 381 week of pregnancy than the lowest value at the 42' week in healthy pregnant women. We suppose that a relatively magnesium depleted state during pregnancy can contribute to the development of preeclampsia. Magnesium support throughout pregnancy thus might be special significance.
|Publication status||Published - Dec 1 1996|
ASJC Scopus subject areas
- Molecular Biology