Objective: To analyze the changes of different neuropeptide-containning nerve fibres in iodoacetamine-induced gastritis, and the relationship between the nerve fibres and immune cells. Methods: The animal models with gastritis were induced by iodoacetamide. Controls received water. Gastric specimens from the control and the model groups were examined by immunohistochemistry and immunocytochemistry and the changes of these fibres containing-Substance P (SP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) and immunocompetent cells were analyzed. Results: The nerve fibres showing immunoreactivity for SP, VIP and NPY were seen in all layers of the stomach. Nerve fibres containing-SP and VIP increased significantly in model group (P<0.05). Immunocompetent cells could be found in mucosa in model group, which were lymphocytes, plasma cells, and mast cells. Immunocompetent cells were very near the fibres. Conclusion: The model with mild iodoacetamide-induced gastritis is built successfully. Neuropeptides participate in the processes of gastritis and might involve in neuroimmunomodulation in gastritis.
|Number of pages||3|
|Journal||Journal of Jilin University Medicine Edition|
|Publication status||Published - Jan 1 2007|
- Nerve fibres
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