Changes of functional residual capacity in hemorrhagic shock. Role of the respiratory muscles

S. Nagy, Z. Hantos, J. Klebniczki

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Hyperventilation is a cardinal feature of shock. It is an important compensatory mechanism for the metabolic acidosis, by removing large amounts of carbon dioxide from the body. Because of the increased energy consumption of the respiratory muscles it imposes a significant demand on the diminished energy resources of the organism. In experimental hemorrhagic shock the elevated minute ventilation is maintained for hours, then it falls towards or below the control level and the animals die in respiratory failure preceding the breakdown of the circulation. The mechanism behind the cessation of hyperventilation in late shock is not known. Clearly, factors that may affect the state of the respiratory muscles should be investigated. In shock the oxygen demands of the respiratory muscles may be a very significant fraction of the total oxygen supply to the body. It is of considerable importance therefore to study the changes in the mechanical properties of the respiratory system during shock because these will determine to a large extent the work of breathing and thus influence the critical energy balance in this condition.

Original languageEnglish
Pages (from-to)111-128
Number of pages18
JournalFernstrom Foundation Series
VolumeVOL. 3
Publication statusPublished - Jan 1 1983


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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