A kilégzett nitrogén-monoxid koncentrációjának változása a tüdó akut ischaemia-reperfuziós károsodásaiban.

Translated title of the contribution: Changes of exhaled nitrogen-monoxide concentration in acute ischemia-reperfusion injury of the lung

Tamás Kövesi, David Royston, Magdi Yacoub, E. Rőth, Nándor Marczin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION: Nitric oxide (NO) plays an important role in both the physiological control of the pulmonary vascular bed and in the pathophysiology of several lung diseases. Though our knowledge regarding NO has became wider several aspects are still a matter of debate. The technical developments allowing direct measurements of NO in the expired air have provided an opportunity to evaluate NO production and consumption in the clinical setting and exhaled NO has become a diagnostic and monitoring tool in acute and chronic lung diseases. AIMS: The aim of our study was to evaluate the severity of different levels of ischaemia-reperfusion related lung injury by measuring nitric oxide in the exhaled air. After presenting our data regarding exhaled NO in ischaemia-reperfusion related acute lung injury associated with cardiothoracic surgery we discuss the physiology of exhaled NO and the technical aspects of measuring NO in the expired breath. METHODS: Comparing basal and GTN-induced exhaled NO data after two types of heart and lung surgery--routine open-heart surgery utilizing CPB and lung transplantation--we studied the effects of different levels of lung ischaemia on NO production. RESULTS: Following transient and incomplete lung ischaemia in the clinical setting of routine cardiac surgery utilizing cardiopulmonary bypass (CPB) both the airway epithelial and the vascular endothelial function remained preserved. However, prolonged and complete lung ischaemia during lung transplantation was associated with severe dysfunction resulted in a marked reduction of both the endogen and the induced levels of exhaled NO.

Original languageHungarian
Pages (from-to)2393-2398
Number of pages6
JournalOrvosi Hetilap
Volume143
Issue number42
Publication statusPublished - Oct 20 2002

Fingerprint

Reperfusion Injury
Nitric Oxide
Lung
Ischemia
Thoracic Surgery
Lung Transplantation
Cardiopulmonary Bypass
Lung Diseases
Reperfusion
Blood Vessels
Air
Acute Lung Injury
Lung Injury
Chronic Disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A kilégzett nitrogén-monoxid koncentrációjának változása a tüdó akut ischaemia-reperfuziós károsodásaiban. / Kövesi, Tamás; Royston, David; Yacoub, Magdi; Rőth, E.; Marczin, Nándor.

In: Orvosi Hetilap, Vol. 143, No. 42, 20.10.2002, p. 2393-2398.

Research output: Contribution to journalArticle

Kövesi, Tamás ; Royston, David ; Yacoub, Magdi ; Rőth, E. ; Marczin, Nándor. / A kilégzett nitrogén-monoxid koncentrációjának változása a tüdó akut ischaemia-reperfuziós károsodásaiban. In: Orvosi Hetilap. 2002 ; Vol. 143, No. 42. pp. 2393-2398.
@article{9614196107d64ae29dcf52340197ba3b,
title = "A kil{\'e}gzett nitrog{\'e}n-monoxid koncentr{\'a}ci{\'o}j{\'a}nak v{\'a}ltoz{\'a}sa a t{\"u}d{\'o} akut ischaemia-reperfuzi{\'o}s k{\'a}rosod{\'a}saiban.",
abstract = "INTRODUCTION: Nitric oxide (NO) plays an important role in both the physiological control of the pulmonary vascular bed and in the pathophysiology of several lung diseases. Though our knowledge regarding NO has became wider several aspects are still a matter of debate. The technical developments allowing direct measurements of NO in the expired air have provided an opportunity to evaluate NO production and consumption in the clinical setting and exhaled NO has become a diagnostic and monitoring tool in acute and chronic lung diseases. AIMS: The aim of our study was to evaluate the severity of different levels of ischaemia-reperfusion related lung injury by measuring nitric oxide in the exhaled air. After presenting our data regarding exhaled NO in ischaemia-reperfusion related acute lung injury associated with cardiothoracic surgery we discuss the physiology of exhaled NO and the technical aspects of measuring NO in the expired breath. METHODS: Comparing basal and GTN-induced exhaled NO data after two types of heart and lung surgery--routine open-heart surgery utilizing CPB and lung transplantation--we studied the effects of different levels of lung ischaemia on NO production. RESULTS: Following transient and incomplete lung ischaemia in the clinical setting of routine cardiac surgery utilizing cardiopulmonary bypass (CPB) both the airway epithelial and the vascular endothelial function remained preserved. However, prolonged and complete lung ischaemia during lung transplantation was associated with severe dysfunction resulted in a marked reduction of both the endogen and the induced levels of exhaled NO.",
author = "Tam{\'a}s K{\"o}vesi and David Royston and Magdi Yacoub and E. Rőth and N{\'a}ndor Marczin",
year = "2002",
month = "10",
day = "20",
language = "Hungarian",
volume = "143",
pages = "2393--2398",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "42",

}

TY - JOUR

T1 - A kilégzett nitrogén-monoxid koncentrációjának változása a tüdó akut ischaemia-reperfuziós károsodásaiban.

AU - Kövesi, Tamás

AU - Royston, David

AU - Yacoub, Magdi

AU - Rőth, E.

AU - Marczin, Nándor

PY - 2002/10/20

Y1 - 2002/10/20

N2 - INTRODUCTION: Nitric oxide (NO) plays an important role in both the physiological control of the pulmonary vascular bed and in the pathophysiology of several lung diseases. Though our knowledge regarding NO has became wider several aspects are still a matter of debate. The technical developments allowing direct measurements of NO in the expired air have provided an opportunity to evaluate NO production and consumption in the clinical setting and exhaled NO has become a diagnostic and monitoring tool in acute and chronic lung diseases. AIMS: The aim of our study was to evaluate the severity of different levels of ischaemia-reperfusion related lung injury by measuring nitric oxide in the exhaled air. After presenting our data regarding exhaled NO in ischaemia-reperfusion related acute lung injury associated with cardiothoracic surgery we discuss the physiology of exhaled NO and the technical aspects of measuring NO in the expired breath. METHODS: Comparing basal and GTN-induced exhaled NO data after two types of heart and lung surgery--routine open-heart surgery utilizing CPB and lung transplantation--we studied the effects of different levels of lung ischaemia on NO production. RESULTS: Following transient and incomplete lung ischaemia in the clinical setting of routine cardiac surgery utilizing cardiopulmonary bypass (CPB) both the airway epithelial and the vascular endothelial function remained preserved. However, prolonged and complete lung ischaemia during lung transplantation was associated with severe dysfunction resulted in a marked reduction of both the endogen and the induced levels of exhaled NO.

AB - INTRODUCTION: Nitric oxide (NO) plays an important role in both the physiological control of the pulmonary vascular bed and in the pathophysiology of several lung diseases. Though our knowledge regarding NO has became wider several aspects are still a matter of debate. The technical developments allowing direct measurements of NO in the expired air have provided an opportunity to evaluate NO production and consumption in the clinical setting and exhaled NO has become a diagnostic and monitoring tool in acute and chronic lung diseases. AIMS: The aim of our study was to evaluate the severity of different levels of ischaemia-reperfusion related lung injury by measuring nitric oxide in the exhaled air. After presenting our data regarding exhaled NO in ischaemia-reperfusion related acute lung injury associated with cardiothoracic surgery we discuss the physiology of exhaled NO and the technical aspects of measuring NO in the expired breath. METHODS: Comparing basal and GTN-induced exhaled NO data after two types of heart and lung surgery--routine open-heart surgery utilizing CPB and lung transplantation--we studied the effects of different levels of lung ischaemia on NO production. RESULTS: Following transient and incomplete lung ischaemia in the clinical setting of routine cardiac surgery utilizing cardiopulmonary bypass (CPB) both the airway epithelial and the vascular endothelial function remained preserved. However, prolonged and complete lung ischaemia during lung transplantation was associated with severe dysfunction resulted in a marked reduction of both the endogen and the induced levels of exhaled NO.

UR - http://www.scopus.com/inward/record.url?scp=0037145288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037145288&partnerID=8YFLogxK

M3 - Article

C2 - 12440262

AN - SCOPUS:0037145288

VL - 143

SP - 2393

EP - 2398

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 42

ER -