Changes of cerebral hemodynamics in hypertensives during physical exercise

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Abstract

Background and Purpose. Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters were compared with those of age-matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives were investigated again. The aim of this study was to compare the cerebral hemodynamic changes in the regularly treated and noncompliant (untreated) hypertensives during ergometer cycling. Methods. Nineteen of 30 previously untreated hypertensive patients could be investigated again using the same method as before. Eleven were regularly treated (treated hypertensive [T-HT] group), and 8 did not take their AHT medications due to lack of compliance (noncompliant hypertensive [NC-HT] group). Blood pressure, heart rate, end-tidal CO2 (etCO2; Capnogard capnograph), and bilateral middle cerebral artery mean blood flow velocity (MV) were continuously monitored during ergometer cycling according to the World Health Organization protocol. Values of 2-minute loading were analyzed. Results. Median loading time did not differ significantly between the T-HT and NC-HT groups. After 2 minutes of cycling in treated patients, the ratio of MV and etCO changes (ΔMV/ΔetCO2) showed similar values as before therapy (P = .38), whereas in noncompliant patients, a further worsening of the ratio of ΔMW/ΔetCO2 could be observed (P = .04). Conclusion. The decrease of arteriolar vasodilation (ie, the ratio of ΔMW/ΔetCO 2) could be demonstrated in the NC-HT group after 3 years. TCD combined with ergometer cycling is a useful method for evaluation of cerebral hemodynamic changes after AHT therapy.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalJournal of Neuroimaging
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Hemodynamics
Exercise
Antihypertensive Agents
Blood Flow Velocity
Middle Cerebral Artery
Vasodilation
Compliance
Healthy Volunteers
Therapeutics
Heart Rate
Blood Pressure

Keywords

  • Cerebral hemodynamics
  • Hypertension
  • Physical exercise
  • Transcranial Doppler

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

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title = "Changes of cerebral hemodynamics in hypertensives during physical exercise",
abstract = "Background and Purpose. Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters were compared with those of age-matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives were investigated again. The aim of this study was to compare the cerebral hemodynamic changes in the regularly treated and noncompliant (untreated) hypertensives during ergometer cycling. Methods. Nineteen of 30 previously untreated hypertensive patients could be investigated again using the same method as before. Eleven were regularly treated (treated hypertensive [T-HT] group), and 8 did not take their AHT medications due to lack of compliance (noncompliant hypertensive [NC-HT] group). Blood pressure, heart rate, end-tidal CO2 (etCO2; Capnogard capnograph), and bilateral middle cerebral artery mean blood flow velocity (MV) were continuously monitored during ergometer cycling according to the World Health Organization protocol. Values of 2-minute loading were analyzed. Results. Median loading time did not differ significantly between the T-HT and NC-HT groups. After 2 minutes of cycling in treated patients, the ratio of MV and etCO changes (ΔMV/ΔetCO2) showed similar values as before therapy (P = .38), whereas in noncompliant patients, a further worsening of the ratio of ΔMW/ΔetCO2 could be observed (P = .04). Conclusion. The decrease of arteriolar vasodilation (ie, the ratio of ΔMW/ΔetCO 2) could be demonstrated in the NC-HT group after 3 years. TCD combined with ergometer cycling is a useful method for evaluation of cerebral hemodynamic changes after AHT therapy.",
keywords = "Cerebral hemodynamics, Hypertension, Physical exercise, Transcranial Doppler",
author = "M. Magyar and A. Valikovics and I. Czuriga and L. Csiba",
year = "2005",
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doi = "10.1177/1051228404269492",
language = "English",
volume = "15",
pages = "64--69",
journal = "Journal of Neuroimaging",
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T1 - Changes of cerebral hemodynamics in hypertensives during physical exercise

AU - Magyar, M.

AU - Valikovics, A.

AU - Czuriga, I.

AU - Csiba, L.

PY - 2005/1

Y1 - 2005/1

N2 - Background and Purpose. Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters were compared with those of age-matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives were investigated again. The aim of this study was to compare the cerebral hemodynamic changes in the regularly treated and noncompliant (untreated) hypertensives during ergometer cycling. Methods. Nineteen of 30 previously untreated hypertensive patients could be investigated again using the same method as before. Eleven were regularly treated (treated hypertensive [T-HT] group), and 8 did not take their AHT medications due to lack of compliance (noncompliant hypertensive [NC-HT] group). Blood pressure, heart rate, end-tidal CO2 (etCO2; Capnogard capnograph), and bilateral middle cerebral artery mean blood flow velocity (MV) were continuously monitored during ergometer cycling according to the World Health Organization protocol. Values of 2-minute loading were analyzed. Results. Median loading time did not differ significantly between the T-HT and NC-HT groups. After 2 minutes of cycling in treated patients, the ratio of MV and etCO changes (ΔMV/ΔetCO2) showed similar values as before therapy (P = .38), whereas in noncompliant patients, a further worsening of the ratio of ΔMW/ΔetCO2 could be observed (P = .04). Conclusion. The decrease of arteriolar vasodilation (ie, the ratio of ΔMW/ΔetCO 2) could be demonstrated in the NC-HT group after 3 years. TCD combined with ergometer cycling is a useful method for evaluation of cerebral hemodynamic changes after AHT therapy.

AB - Background and Purpose. Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters were compared with those of age-matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives were investigated again. The aim of this study was to compare the cerebral hemodynamic changes in the regularly treated and noncompliant (untreated) hypertensives during ergometer cycling. Methods. Nineteen of 30 previously untreated hypertensive patients could be investigated again using the same method as before. Eleven were regularly treated (treated hypertensive [T-HT] group), and 8 did not take their AHT medications due to lack of compliance (noncompliant hypertensive [NC-HT] group). Blood pressure, heart rate, end-tidal CO2 (etCO2; Capnogard capnograph), and bilateral middle cerebral artery mean blood flow velocity (MV) were continuously monitored during ergometer cycling according to the World Health Organization protocol. Values of 2-minute loading were analyzed. Results. Median loading time did not differ significantly between the T-HT and NC-HT groups. After 2 minutes of cycling in treated patients, the ratio of MV and etCO changes (ΔMV/ΔetCO2) showed similar values as before therapy (P = .38), whereas in noncompliant patients, a further worsening of the ratio of ΔMW/ΔetCO2 could be observed (P = .04). Conclusion. The decrease of arteriolar vasodilation (ie, the ratio of ΔMW/ΔetCO 2) could be demonstrated in the NC-HT group after 3 years. TCD combined with ergometer cycling is a useful method for evaluation of cerebral hemodynamic changes after AHT therapy.

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