Changes of brain evoked potentials caused by dimethoate treatment in three generations of rats

Research output: Contribution to journalArticle

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Abstract

Wistar rats were continuously treated with 7.0, 10.5, 14.0, and 28.0 mg/kg (1/100, 1/70, 1/50 and 1/25 LD50) of dimethoate per os including the pregnancy and lactation periods for three subsequent generations. The somatosensory, visual and auditory evoked brain potentials of male rats of each generation were registered at the age of 12-13 weeks with silver electrodes placed on the primary somatosensory, visual and auditory cortex. The measured parameters were the latency and duration of the evoked potentials. There were differences in the changes among the various evoked potentials in all of the generations. The strongest effect caused by dimethoate was seen in the case of the somatosensory evoked potentials compared to the control. The changes of the visual and auditory evoked potentials were milder. Comparing the changes of the evoked potentials of the three generations it was found that there were no significant changes between the data of the three populations.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
JournalNeuroToxicology
Volume15
Issue number3
Publication statusPublished - 1994

Fingerprint

Dimethoate
Bioelectric potentials
Evoked Potentials
Rats
Brain
Auditory Evoked Potentials
Auditory Cortex
Somatosensory Cortex
Somatosensory Evoked Potentials
Visual Evoked Potentials
Lethal Dose 50
Visual Cortex
Silver
Lactation
Wistar Rats
Electrodes
Pregnancy
Population

Keywords

  • Dimethoate
  • Evoked Potentials
  • Male Wistar Rats
  • Organophosphates

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Changes of brain evoked potentials caused by dimethoate treatment in three generations of rats. / Nagymajtényi, L.; Dési, I.; Schulz, H.

In: NeuroToxicology, Vol. 15, No. 3, 1994, p. 741-744.

Research output: Contribution to journalArticle

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