Changes induced by vascular antigens in the aorta of guinea-pigs: Immunological and morphological studies

J. Fehér, M. Horvath, E. Fehér, E. Szondy, K. Onody, S. Gerö

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects have been studied of human vessel wall on the cell-mediated and humoral immune response, as well as the morphological changes produced in the aorta in guinea-pigs. In animals immunized with calcium chloride-tris-citrate extracts of the aortic and vessel wall a definite cell-mediated and humoral immune response was observed. A cross-reaction was found between the 2 vessel wall extracts in the skin test and in the migration inhibition test. The induction of desoxyribonucleic acid synthesis was found to be specific. Antibody production as well as the concentration of IgG in the serum was increased. Simultaneously with increased production of the antibodies the cellular immune response did not diminish until the 9th wk. A definite alteration was found in the aortic intima by histological, histochemical, immunofluorescence and electron microscopic methods. In addition, some slight changes could be observed in the media and in the adventitia of the aorta.

Original languageEnglish
Pages (from-to)237-247
Number of pages11
JournalBritish Journal of Experimental Pathology
Volume59
Issue number3
Publication statusPublished - 1978

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Humoral Immunity
Antibody Formation
Blood Vessels
Aorta
Guinea Pigs
Antigens
Adventitia
Calcium Chloride
Cross Reactions
Skin Tests
Cellular Immunity
Citric Acid
Cell Wall
Fluorescent Antibody Technique
Immunoglobulin G
Electrons
Acids
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Changes induced by vascular antigens in the aorta of guinea-pigs : Immunological and morphological studies. / Fehér, J.; Horvath, M.; Fehér, E.; Szondy, E.; Onody, K.; Gerö, S.

In: British Journal of Experimental Pathology, Vol. 59, No. 3, 1978, p. 237-247.

Research output: Contribution to journalArticle

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