Changes induced by Gramoxon® in tissue phospholipids and phospholipid fatty acids in mouse and guinea-pig

Katalin Barabás, B. Matkovics, L. Szabó, Sz I. Varga, L. Vigh, I. Horváth, G. Berencsi

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Abstract

1. 1. Following administration of the LD50 or the LD100 of Gramoxon® (PQ), the phospholipids (PL) of the lung, liver and kidney were separated and both the PLs and the fatty acids isolable from them were examined quantitatively. 2. 2. The different doses of PQ caused different changes of the saturated and unsaturated fatty acids in the various organs. 3. 3. The changes in the PL unsaturated fatty acids point to PQ-induced lipid peroxidation enhancement and membrane damage.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalGeneral Pharmacology
Volume14
Issue number5
DOIs
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Pharmacology

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