A vizeletenzimek aktivitásváltozása vesicoureteralis reflux szilikonnal végzett kezelésében.

Translated title of the contribution: Changes in urinary enzyme activity following silicon therapy of vesico-ureteral reflux

G. Rákóczy, G. Reusz, P. Sallay, E. Németh, I. Várkonyi

Research output: Contribution to journalReview article

Abstract

The urinary enzymes Gamma Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Leucine-Arylamidase (LAS) and Dipeptidyl-Peptidase-IV (DPP-IV) were measured before and after endoscopic treatment of vesico-ureteric reflux (VUR) in two groups of twenty children's. Ten patients had undergone successful endoscopic corrective surgery for VUR, another 10 patients had unsuccessful endoscopic intervention. After successful treatment the activity of LAS in the urine did not change, but that of GGT, ALP and DDP-IV activity in the urine was 2-5 times higher than before treatment (P < 0.03 for all three enzymes). Considerable changes of urinary enzymes' activity were not observed following unsuccessful endoscopic treatment. Our data and the literature are contradictory. However this contradiction might be explained by the differences in urine sampling methods. Our patients received the same chemoprofilactic drug at the time of both urine sampling, a point not considered by other researchers. The extent of increase of enzyme activity after endoscopic treatment of VUR did not reach the level that would permit the use of investigated enzymes for screening, because the observed changes did not exceed the limits of the normal range.

Translated title of the contributionChanges in urinary enzyme activity following silicon therapy of vesico-ureteral reflux
Original languageHungarian
Pages (from-to)951-954
Number of pages4
JournalOrvosi hetilap
Volume139
Issue number16
Publication statusPublished - Apr 19 1998

ASJC Scopus subject areas

  • Medicine(all)

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