Changes in the vasopressin content of discrete brain regions in response to stimuli for vasopressin secretion

Robert L. Zerbe, M. Palkóvits

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

In order to better understand the function of vasopressin-containing axons which project to areas outside the hypothalamus, we measured vasopressin content in hypothalamic and extrahypothalamic brain regions following various periods of oral hypertonic saline or 1 week after pituitary stalk section. The supraoptic and paraventricular nuclei and nearly all of the brain regions examined which are known to receive vasopressin-containing axons from these nuclei showed parallel changes in vasopressin levels in response to both stimuli. In response to hypertonic saline there was an initial rise followed by a fall in vasopressin content. The suprachiasmatic and lateral septal nuclei, as well as the nucleus of the solitary tract, were unaffected by either stimulus. These results indicate that there are at least two functionally different vasopressin systems within the central nervous system, one of which is responsive to osmotic stimulation.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalNeuroendocrinology
Volume38
Issue number4
DOIs
Publication statusPublished - 1984

Fingerprint

Vasopressins
Brain
Axons
Supraoptic Nucleus
Septal Nuclei
Solitary Nucleus
Paraventricular Hypothalamic Nucleus
Pituitary Gland
Hypothalamus
Central Nervous System

Keywords

  • Extrahypothalamic brain regions
  • Hypothalamus
  • Osmotic stimulation
  • Pituitary stalk transection
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Changes in the vasopressin content of discrete brain regions in response to stimuli for vasopressin secretion. / Zerbe, Robert L.; Palkóvits, M.

In: Neuroendocrinology, Vol. 38, No. 4, 1984, p. 285-289.

Research output: Contribution to journalArticle

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