Changes in the plasma concentration of soluble thrombomodulin in patients with severe carotid artery stenosis after eversion endarterectomy

E. Dósa, A. Szabó, Z. Prohászka, I. Karádi, S. Rugonfalvi-Kiss, A. Apor, Z. Járányi, K. Hüttl, L. Selmeci, G. Acsády, G. Füst, L. Entz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective and design: The purpose of the study was to investigate the putative role of soluble thrombomodulin (sTM) in severe carotid artery stenosis. Materials and methods: We prospectively studied 64 patients who were undergoing carotid endarterectomy (2001-2003). Plasma sTM concentration was determined in each patient before surgery and at 14 months postsurgery. -308 TNF-α promoter polymorphism was also determined. Results: Strong negative correlation was found between the preoperative duplex scan values and the plasma sTM concentrations (R = -0.418, p = 0.0006). Patients with 308 A TNF-α genotype had significantly lower (p = 0.0415) preoperative sTM values than their counterparts with no such polymorphism. Soluble TM concentrations measured in plasma samples taken at the end of the postsurgical follow-up period of 14 months duration were significantly higher compared to the preoperative values (p <0.0001). Conclusions: Our present findings indicate that sTM may be adsorbed to the atherosclerotic plaques or inflamed endothelium in carotid arteries. The pathological significance of this adsorption remains to be determined.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalInflammation Research
Volume54
Issue number7
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Thrombomodulin
Endarterectomy
Carotid Stenosis
Plasmas
Polymorphism
Carotid Endarterectomy
Atherosclerotic Plaques
Carotid Arteries
Surgery
Adsorption
Endothelium
Genotype

Keywords

  • Atherosclerosis
  • Endarterectomy
  • Restenosis
  • Thrombomodulin
  • TNF-α

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Changes in the plasma concentration of soluble thrombomodulin in patients with severe carotid artery stenosis after eversion endarterectomy. / Dósa, E.; Szabó, A.; Prohászka, Z.; Karádi, I.; Rugonfalvi-Kiss, S.; Apor, A.; Járányi, Z.; Hüttl, K.; Selmeci, L.; Acsády, G.; Füst, G.; Entz, L.

In: Inflammation Research, Vol. 54, No. 7, 07.2005, p. 289-294.

Research output: Contribution to journalArticle

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