Changes in the patching and capping of insulin receptors under the influence of hormonal imprinting

P. Kovács, O. Török, G. Csaba

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Abstract

Binding of fluorescein-isothiocyanate-(FITC)-labeled insulin was followed up in the function of time in Chang liver cells pretreated and not pretreated with insulin. The not pretreated cells showed patching, but no capping of the receptors during the period of study (60 min), whereas the insulin-pretreated cells showed indications of capping already after 10 min. Patching of the insulin receptors was particularly conspicuous at the sites of cell-cell contact (at the intercellular junctions). Supra-nuclear patching occurred earlier in the control cultures, and on it followed the fluorescence of the nuclear chromatin.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalHistochemistry
Volume90
Issue number3
DOIs
Publication statusPublished - May 1988

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Insulin Receptor
Receptor Aggregation
Insulin
Intercellular Junctions
Fluorescein
Chromatin
Fluorescence
Liver

ASJC Scopus subject areas

  • Anatomy

Cite this

Changes in the patching and capping of insulin receptors under the influence of hormonal imprinting. / Kovács, P.; Török, O.; Csaba, G.

In: Histochemistry, Vol. 90, No. 3, 05.1988, p. 241-244.

Research output: Contribution to journalArticle

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