Changes in the fine structure and function of a hormone-secreting adrenocortical tumour investigated in tissue culture

D. Szabó, A. Gyévai, E. Gláz, E. Stark, M. Péteri, O. Alánt

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Abstract

Tissue cultures of a surgically removed adrenocortical tumour causing Cushing's syndrome, and tissue cultures from the attached, tumour-free adrenal were studied. There were two cell types characteristic of tumour tissue. The cell type occurring most frequently had pronounced hypertrophied agranular endoplasmic reticulum. A fewer number of lipid-rich cells containing many electron-dense granules could also be found. The ratio of cells changed during cultivation. In the 17 days tumour culture, a higher percentage of lipid-rich cells could be observed. In spite of continuous ACTH treatment, the initially high hydrocortisone level decreased, gradually. It may be assumed that the lipid-rich cells are of reduced ability as regards hydrocortisone production.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume367
Issue number4
DOIs
Publication statusPublished - Dec 1 1975

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ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology

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