Changes in the fine structure and function of a hormone secreting adrenocortical tumor in tissue culture (Hungarian)

D. Szabo, A. Gyevai, E. Gláz

Research output: Contribution to journalArticle

Abstract

Tissue cultures of a surgically removed adrenocortical tumour causing Cushing's syndrome, and tissue cultures from the attached, tumour free adrenal were studied. There were two cell types characteristic of tumour tissue. The cell type occurring most frequently had pronounced hypertrophied agranular endoplasmic reticulum. A smaller number of lipid rich cells containing many electron dense granules could also be found. The ratio of cells changed during cultivation. In the 17 days tumour culture, a higher percentage of lipid rich cells could be observed. In spite of continuous ACTH treatment, the initially high hydrocortisone level decreased, gradually. It may be assumed that the lipid rich cells are of reduced ability as regards hydrocortisone production.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalMorphologiai es igazsagugyi orvosi szemle
Volume15
Issue number4
Publication statusPublished - 1975

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Hormones
Neoplasms
Lipids
Hydrocortisone
Smooth Endoplasmic Reticulum
Cushing Syndrome
Adrenocorticotropic Hormone
Electrons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Changes in the fine structure and function of a hormone secreting adrenocortical tumor in tissue culture (Hungarian). / Szabo, D.; Gyevai, A.; Gláz, E.

In: Morphologiai es igazsagugyi orvosi szemle, Vol. 15, No. 4, 1975, p. 243-248.

Research output: Contribution to journalArticle

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