Changes in specific binding sites of girisopam after chemical and surgical lesions in the striato-nigral system

Edit J. Horváth, M. Fekete, M. Palkóvits

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalMolecular Brain Research
Volume45
Issue number1
DOIs
Publication statusPublished - Apr 1997

Fingerprint

Substantia Nigra
Binding Sites
Corpus Striatum
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Afferent Pathways
Neurons
Caudate Nucleus
Neurotoxins
Benzodiazepines
girisopam
Injections

Keywords

  • 2,3-Benzodiazepine
  • AMPA
  • Autoradiography
  • Girisopam
  • Striatal lesion
  • Striato-nigral transection

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Changes in specific binding sites of girisopam after chemical and surgical lesions in the striato-nigral system. / Horváth, Edit J.; Fekete, M.; Palkóvits, M.

In: Molecular Brain Research, Vol. 45, No. 1, 04.1997, p. 141-144.

Research output: Contribution to journalArticle

@article{5f5602fc37ee4762aad537617e490d14,
title = "Changes in specific binding sites of girisopam after chemical and surgical lesions in the striato-nigral system",
abstract = "Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.",
keywords = "2,3-Benzodiazepine, AMPA, Autoradiography, Girisopam, Striatal lesion, Striato-nigral transection",
author = "Horv{\'a}th, {Edit J.} and M. Fekete and M. Palk{\'o}vits",
year = "1997",
month = "4",
doi = "10.1016/S0169-328X(96)00293-8",
language = "English",
volume = "45",
pages = "141--144",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Changes in specific binding sites of girisopam after chemical and surgical lesions in the striato-nigral system

AU - Horváth, Edit J.

AU - Fekete, M.

AU - Palkóvits, M.

PY - 1997/4

Y1 - 1997/4

N2 - Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.

AB - Neurotoxin (AMPA)-induced lesions in the caudate nucleus as well as unilateral surgical transection of the striato-nigral pathway strongly depleted the binding of a homophthalazine (formerly called 2,3-benzodiazepines) girisopam (GYKI-51189, EGIS 5810) selectively in the substantia nigra of the rat, ipsilateral to the lesions. In contrast to this, AMPA injections into the substantia nigra failed to effect on girisopam binding to either components of the nigro-striatal system. Data indicate that this homophthalazine may bind to a descending component of the striatum (striato-nigral projecting neurons), or its binding capacity to substantia nigra neurons depends on the integrity of striatal afferent pathways to the substantia nigra.

KW - 2,3-Benzodiazepine

KW - AMPA

KW - Autoradiography

KW - Girisopam

KW - Striatal lesion

KW - Striato-nigral transection

UR - http://www.scopus.com/inward/record.url?scp=0031127524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031127524&partnerID=8YFLogxK

U2 - 10.1016/S0169-328X(96)00293-8

DO - 10.1016/S0169-328X(96)00293-8

M3 - Article

C2 - 9105681

AN - SCOPUS:0031127524

VL - 45

SP - 141

EP - 144

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -