Changes in skeletal muscle morphology and biochemistry after cardiac transplantation

Lizanne M. Bussières, Peter W. Pflugfelder, A. Taylor, Earl G. Noble, William J. Kostuk

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Skeletal muscle biopsies (vastus lateralis) were performed in 12 patients (mean age 47 ± 11 years) before and at 3 and 12 months after cardiac transplantation. Fiber type analysis revealed a predominance of type II fibers before cardiac transplantation (66 ± 10%); the ratio did not change after transplantation. Fiber crosssectional area increased by 35% to 39% in all fiber types by 12 months after cardiac transplantation. Fiber cross-sectional area, however, remained below the reported normal values. The number of capillaries surrounding each fiber did not change after cardiac transplantation. Skeletal muscle enzyme activity of phosphofructokinase, citrate synthase, and β-hydroxyacyl coenzyme A dehydrogenase increased by 96%, 47%, and 63%, respectively, after cardiac transplantation (p

Original languageEnglish
Pages (from-to)630-634
Number of pages5
JournalThe American journal of cardiology
Volume79
Issue number5
DOIs
Publication statusPublished - Mar 1 1997

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Heart Transplantation
Biochemistry
Skeletal Muscle
Citrate (si)-Synthase
Phosphofructokinases
Quadriceps Muscle
Coenzyme A
Oxidoreductases
Reference Values
Transplantation
Biopsy
Enzymes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Changes in skeletal muscle morphology and biochemistry after cardiac transplantation. / Bussières, Lizanne M.; Pflugfelder, Peter W.; Taylor, A.; Noble, Earl G.; Kostuk, William J.

In: The American journal of cardiology, Vol. 79, No. 5, 01.03.1997, p. 630-634.

Research output: Contribution to journalArticle

Bussières, Lizanne M. ; Pflugfelder, Peter W. ; Taylor, A. ; Noble, Earl G. ; Kostuk, William J. / Changes in skeletal muscle morphology and biochemistry after cardiac transplantation. In: The American journal of cardiology. 1997 ; Vol. 79, No. 5. pp. 630-634.
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