Changes in respiratory mechanics during cardiac surgery

Barna Babik, Tibor Asztalos, F. Peták, Zoltán I. Deák, Z. Hantos

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We investigated the role of cardiopulmonary bypass (CPB) in compromised lung function associated with cardiac surgery. Low-frequency respiratory impedance (Zrs) was measured in patients undergoing cardiac surgery with (n = 30; CPB group) or without (n = 29; off-pump coronary artery bypass [OPCAB] group) CPB. Another group of CPB patients received dopamine (DA) (n = 12; CPB-DA group). Extravascular lung water was determined in five CPB subjects. Zrs was measured before skin incision and after chest closure. Airway resistance and inertance and tissue damping and elastance were determined from Zrs data. Airway resistance increased in the CPB group (74.9% ± 20.8%; P <0.05), whereas it did not change in the OPCAB group (11.8% ± 7.9%; not significant) and even decreased in the CPB-DA patients (-40.6% ± 9.2%; P <0.05). Tissue damping increased in the CPB and OPCAB groups, whereas it remained constant in the CPB-DA patients. Significant increases in elastance were observed in all groups. There was no difference in extravascular lung water before and after CPB, suggesting that edema did not develop. These results indicate a significant and heterogeneous airway narrowing during CPB, which was counteracted by the administration of DA. The mild deterioration in tissue mechanics, reflecting partial closure of the airways, may be a consequence of the anesthesia itself.

Original languageEnglish
Pages (from-to)1280-1287
Number of pages8
JournalAnesthesia and Analgesia
Volume96
Issue number5
Publication statusPublished - May 1 2003

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Respiratory Mechanics
Cardiopulmonary Bypass
Thoracic Surgery
Dopamine
Off-Pump Coronary Artery Bypass
Extravascular Lung Water
Airway Resistance
Mechanics
Electric Impedance
Edema

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Changes in respiratory mechanics during cardiac surgery. / Babik, Barna; Asztalos, Tibor; Peták, F.; Deák, Zoltán I.; Hantos, Z.

In: Anesthesia and Analgesia, Vol. 96, No. 5, 01.05.2003, p. 1280-1287.

Research output: Contribution to journalArticle

Babik, B, Asztalos, T, Peták, F, Deák, ZI & Hantos, Z 2003, 'Changes in respiratory mechanics during cardiac surgery', Anesthesia and Analgesia, vol. 96, no. 5, pp. 1280-1287.
Babik, Barna ; Asztalos, Tibor ; Peták, F. ; Deák, Zoltán I. ; Hantos, Z. / Changes in respiratory mechanics during cardiac surgery. In: Anesthesia and Analgesia. 2003 ; Vol. 96, No. 5. pp. 1280-1287.
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