Changes in Redox Signaling in the Skeletal Muscle with Aging

P. Szentesi, L. Csernoch, L. Dux, Anikó Keller-Pintér

Research output: Contribution to journalReview article

Abstract

Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality). Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs. Mitochondrial dysfunction and increased oxidative stress are the central driving forces for age-related skeletal muscle abnormalities. The increased oxidative stress in the aged muscle can lead to altered excitation-contraction coupling and calcium homeostasis. Furthermore, apoptosis-mediated fiber loss, atrophy of the remaining fibers, dysfunction of the satellite cells (muscle stem cells), and concomitant impaired muscle regeneration are also the consequences of increased oxidative stress, leading to a decrease in muscle mass, strength, and function of the aged muscle. Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy.

Original languageEnglish
Number of pages1
JournalOxidative medicine and cellular longevity
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

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Oxidation-Reduction
Muscle
Skeletal Muscle
Aging of materials
Muscles
Oxidative Stress
Oxidative stress
Muscle Strength
Excitation Contraction Coupling
Health Care Costs
Muscle Cells
Atrophy
Comorbidity
Regeneration
Homeostasis
Stem Cells
Antioxidants
Fibers
Apoptosis
Calcium

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Changes in Redox Signaling in the Skeletal Muscle with Aging. / Szentesi, P.; Csernoch, L.; Dux, L.; Keller-Pintér, Anikó.

In: Oxidative medicine and cellular longevity, Vol. 2019, 01.01.2019.

Research output: Contribution to journalReview article

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