Changes in progesterone-induced-blocking-factor expression rates following mifepristone administration in termination of pregnancy at 5 to 8 weeks

Laurent J. Salomon, Patrick Rozenberg, J. Szekeres-Barthó, Lydia Malagrida, Yves Giudicelli, Yves Ville

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective. To study changes in the expression rate of PIBF by peripheral lymphocytes in healthy pregnant women after administration of mifepristone for non-surgical termination of pregnancy at 5-8 wks of gestation. Methods. Patients requesting early social termination of pregnancy, in a 3-month period, were included. A first venous blood sample was taken before oral administration of 600 mg of mifepristone (day 0). A second venous blood sample was taken 2 days later. PIBF on lymphocytes was determined by immunocytochemistry using a PIBF-specific polyclonal antibody. Results. Termination of pregnancy was successful and complete in all cases. In 17 out of 21 patients, the percentage of PIBF positive lymphocytes decreased after anti-progesterone administration. The percentage of PIBF-expressing lymphocytes significantly decreased from 52.8% ± 21.6% (day 0) to 39.8% ± 18.2% by day 2 (p = 0.001). Conclusions. These data suggest a strong relationship between early termination of pregnancy induced with mifepristone and disturbances of progesterone-mediated immunosuppression.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume17
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Mifepristone
Progesterone
Pregnancy
Lymphocytes
Immunosuppression
Oral Administration
Pregnant Women
Immunohistochemistry
blocking factor
Antibodies

Keywords

  • Abortion
  • Elective pregnancy termination
  • Immunosuppression
  • Mifeprestone
  • Progesterone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Changes in progesterone-induced-blocking-factor expression rates following mifepristone administration in termination of pregnancy at 5 to 8 weeks. / Salomon, Laurent J.; Rozenberg, Patrick; Szekeres-Barthó, J.; Malagrida, Lydia; Giudicelli, Yves; Ville, Yves.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 17, No. 5, 05.2005, p. 353-356.

Research output: Contribution to journalArticle

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