Changes in plasma and urinary amino acid levels during diabetic ketoacidosis in children

A. Szabó, É Kenesei, A. Körner, M. Miltényi, L. Szücs, I. Nagy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Plasma and urinary concentrations of different amino acids were investigated during diabetic ketoacidosis (DKA) and 12, 24, 72 hours after initiation of therapy. In DKA, plasma concentration of glutamic acid, aspartic acid, valine, leucine and isoleucine significantly increased while that of asparagine and glutamine decreased compared to levels in well-controlled diabetic patients. The urinary excretion of branchedchain amino acids, histidine, serine and threonine was elevated while those of glutamic acid, glutamine, glycine and taurine were reduced. Among the different amino acids, histidine excretion had the highest variability. A strong correlation was found between the urinary excretion of several amino acids and that of the β-2-microglobulin characterizing tubular dysfunction. Changes in the excretion of different amino acids reflect the altered metabolic state and renal function due to DKA.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume12
Issue number2
DOIs
Publication statusPublished - May 1991

Keywords

  • Diabetic ketoacidosis
  • Plasma amino acid
  • Tubular dysfunction
  • Urinary amino acid

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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