Changes in outer membrane protein profiles of bacteria after meropenem- induced postantibiotic effect studied by capillary electrophoresis

Ildikó Kustos, Béla Kocsis, Ildikó Kerepesi, Ferenc Kilár

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13 Citations (Scopus)

Abstract

Persistent inhibition of bacterial growth, called postantibiotic effect (PAE), after a short exposure to a new carbapenem, meropenem, was determined in different strains of the Enterobacteriaceae family. Capillary electrophoresis (CE), as well as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) were used to study the outer membrane protein (OMP) profiles before and after meropenem treatment. CE proved to be suitable for the characterization of the OMP profiles of bacteria. Significant changes in the electrophoretic patterns were observed, showing the consequential effect of meropenem on bacteria.

Original languageEnglish
Pages (from-to)2324-2330
Number of pages7
JournalELECTROPHORESIS
Volume19
Issue number13
DOIs
Publication statusPublished - Oct 1 1998

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Keywords

  • Bacteria
  • Capillary electrophoresis
  • Meropenem
  • Outer membrane proteins
  • Postantibiotic effect

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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