Changes in outer membrane protein profiles of bacteria after meropenem- induced postantibiotic effect studied by capillary electrophoresis

Ildikó Kustos, Béla Kocsis, Ildikó Kerepesi, F. Kilár

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Persistent inhibition of bacterial growth, called postantibiotic effect (PAE), after a short exposure to a new carbapenem, meropenem, was determined in different strains of the Enterobacteriaceae family. Capillary electrophoresis (CE), as well as sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) were used to study the outer membrane protein (OMP) profiles before and after meropenem treatment. CE proved to be suitable for the characterization of the OMP profiles of bacteria. Significant changes in the electrophoretic patterns were observed, showing the consequential effect of meropenem on bacteria.

Original languageEnglish
Pages (from-to)2324-2330
Number of pages7
JournalElectrophoresis
Volume19
Issue number13
DOIs
Publication statusPublished - Oct 1998

Fingerprint

meropenem
Capillary electrophoresis
Capillary Electrophoresis
Bacteria
Membrane Proteins
Carbapenems
Enterobacteriaceae
Electrophoresis
Sodium Dodecyl Sulfate
Polyacrylamide Gel Electrophoresis
Growth

Keywords

  • Bacteria
  • Capillary electrophoresis
  • Meropenem
  • Outer membrane proteins
  • Postantibiotic effect

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Changes in outer membrane protein profiles of bacteria after meropenem- induced postantibiotic effect studied by capillary electrophoresis. / Kustos, Ildikó; Kocsis, Béla; Kerepesi, Ildikó; Kilár, F.

In: Electrophoresis, Vol. 19, No. 13, 10.1998, p. 2324-2330.

Research output: Contribution to journalArticle

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