Comparative electron microscopic examinations of 35 neuromuscular synapses were done in 3 patients with generalized myasthenia accompanied in 2 cases by thymus hyperplasia and in 1 case by lymphoepithelioma of the epithelial type after treatment with anticholinesterase drugs, and 33 neuromuscular synapses in a patient with lymphoepithelioma of the lymphoid type without myasthenia who had not taken the above drugs. Similar changes of the syanpse ultrastructure were found consisting in extension and reduction of the synaptic folds and secondary synaptic splits with the presence in them of granulo-fibrillar substance, and a decrease in the number of synaptic vesicles. It is assumed that ultrastructural changes of postsynaptic membrane in myastenia are nonspecific and are not due to anticholinesterase drugs.
|Number of pages||5|
|Publication status||Published - Jan 1 1979|
ASJC Scopus subject areas
- Pathology and Forensic Medicine