Changes in neurobehavioral parameters and spontaneous cortical activity in rats after acute single and combined exposure by 3-nitropropionic acid and MK-801

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Abstract

In rats, 3-nitropropionic acid (3-NP) produces striatal lesions that mimic certain aspects of pathology in human neurodegenerative diseases. MK-801 was shown to have a neuroprotective effect in 3-NP treated rats. In the present study, neurobehavioral and neurotoxicological effects of 3-NP, MK-801 and their combination were examined. - A single dose of 3-NP (20 mg/kg) and MK-801 (0.4 mg/kg) was given to adult male Wistar rats by intraperitoneal injection. To 10 rats, MK-801 was given first, followed 30 minutes later by 3-NP, another 10 rats got the same drugs in a reverse order. Ten rats were injected with saline. Before and after the treatment, exploratory activity was measured in an open field apparatus. 3-NP decreased open field activity and MK-801, alone, produced a dose-dependent increase in locomotion. After the second injection, both drugs abolished the effect of the other. In the rota-rod test, both 3-NP and MK-801 alone caused a dose dependent decrease in performance. After all behavioral tests, the rats were prepared for electrophysiology under urethane anesthesia, and spontaneous activity was recorded from the exposed primary somatosensory, visual and auditory areas. Cortical activity, mainly the fast bands, was significantly influenced by MK-801 in the somatosensory and visual area. Also here, 3-NP and MK-801 showed antagonism. Our results confirmed by a complex approach that MK-801 acted as a protective agent against 3-NP neurotoxicity. This, in turn reinforced the usability of MK-801 as a potential anti-Parkinson drug.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalHomeostasis in Health and Disease
Volume43
Issue number4
Publication statusPublished - Nov 2005

Fingerprint

Dizocilpine Maleate
3-nitropropionic acid
Pharmaceutical Preparations
Corpus Striatum
Protective Agents
Auditory Cortex
Somatosensory Cortex
Electrophysiology
Urethane
Neuroprotective Agents
Locomotion
Intraperitoneal Injections
Neurodegenerative Diseases
Wistar Rats
Anesthesia
Pathology
Injections

Keywords

  • 3-nitropropionic acid
  • Huntington's disease
  • MK-801
  • Neurotoxicity
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

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title = "Changes in neurobehavioral parameters and spontaneous cortical activity in rats after acute single and combined exposure by 3-nitropropionic acid and MK-801",
abstract = "In rats, 3-nitropropionic acid (3-NP) produces striatal lesions that mimic certain aspects of pathology in human neurodegenerative diseases. MK-801 was shown to have a neuroprotective effect in 3-NP treated rats. In the present study, neurobehavioral and neurotoxicological effects of 3-NP, MK-801 and their combination were examined. - A single dose of 3-NP (20 mg/kg) and MK-801 (0.4 mg/kg) was given to adult male Wistar rats by intraperitoneal injection. To 10 rats, MK-801 was given first, followed 30 minutes later by 3-NP, another 10 rats got the same drugs in a reverse order. Ten rats were injected with saline. Before and after the treatment, exploratory activity was measured in an open field apparatus. 3-NP decreased open field activity and MK-801, alone, produced a dose-dependent increase in locomotion. After the second injection, both drugs abolished the effect of the other. In the rota-rod test, both 3-NP and MK-801 alone caused a dose dependent decrease in performance. After all behavioral tests, the rats were prepared for electrophysiology under urethane anesthesia, and spontaneous activity was recorded from the exposed primary somatosensory, visual and auditory areas. Cortical activity, mainly the fast bands, was significantly influenced by MK-801 in the somatosensory and visual area. Also here, 3-NP and MK-801 showed antagonism. Our results confirmed by a complex approach that MK-801 acted as a protective agent against 3-NP neurotoxicity. This, in turn reinforced the usability of MK-801 as a potential anti-Parkinson drug.",
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