Changes in myosin isozyme distribution induced by low doses of isoproterenol

F. A. Sreter, R. Faris, I. Balogh, E. Somogyi, P. Sotonyi

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Abstract

The Ca 2+-activated myosin ATPase activity in isoproterenol-induced hypertrophied left ventricle increased by 20-30% while in Goldblatt rats hypertrophy occurred with a decreased myosin ATPase activity. In non-dissociating (pyrophosphate) gel electrophoresis isoproterenol treatment showed decreased V 2 and V 3 myosin isozymes; at the higher dose of isoproterenol (0.5 mg/kg body weight) only V 1 was present. In contrast a shift toward the V 3 isozyme is present in the ventricles of Goldblatt rats. One group of rats were treated with toxic doses of digitoxin: no hypertrophy occurred but there was a disappearance of V 1 and V 2 isozymes and a 50% decrease in Ca 2+-activated ATPase activity. Thus low doses of isoproterenol produce hypertrophy with an isozyme pattern similar to that found in young (~4-6 weeks old) rats. The results with digitoxin show that shifts in the cardiac isozyme distribution can occur without hypertrophy.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalArchives internationales de pharmacodynamie et de therapie
Volume260
Issue number1
Publication statusPublished - Dec 1 1982

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ASJC Scopus subject areas

  • Pharmacology

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