Changes in miRNA expression in solid tumors: An miRNA profiling in melanomas

Viktor Molnár, V. Tamási, Beáta Bakos, Zoltán Wiener, A. Falus

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

In this review, we briefly described microRNA biogenesis, function and the principal approaches for studying the function of microRNAs (miRNA) in solid cancers. There are currently hundreds of confirmed miRNAs in humans, and computational predictions suggest that the total count might be more than thousand. The regulatory nature of miRNAs combined with the large number of presumptive target genes suggests that they are essential regulators of a wide range of cellular processes. To illustrate the importance of miRNA-mediated regulation in solid cancer some confirmed interactions were collected. Their relevance is described in detail in melanomas from the aspect of diagnosis, the potential application of miRNAs as biomarkers and as potential therapeutic tools.

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalSeminars in Cancer Biology
Volume18
Issue number2
DOIs
Publication statusPublished - Apr 2008

Fingerprint

MicroRNAs
Melanoma
Neoplasms
Essential Genes
Biomarkers

Keywords

  • Cancer
  • Gene regulation
  • Melanoma
  • MicroRNA
  • Oncogene
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research

Cite this

Changes in miRNA expression in solid tumors : An miRNA profiling in melanomas. / Molnár, Viktor; Tamási, V.; Bakos, Beáta; Wiener, Zoltán; Falus, A.

In: Seminars in Cancer Biology, Vol. 18, No. 2, 04.2008, p. 111-122.

Research output: Contribution to journalArticle

Molnár, Viktor ; Tamási, V. ; Bakos, Beáta ; Wiener, Zoltán ; Falus, A. / Changes in miRNA expression in solid tumors : An miRNA profiling in melanomas. In: Seminars in Cancer Biology. 2008 ; Vol. 18, No. 2. pp. 111-122.
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