A nyelócsó nyálkahártya mikrokeringési változásai akut kísérletes reflux alatt--az epés komponens kóroki szerepe.

Translated title of the contribution: Changes in microcirculation of esophageal mucosa during acute experimental reflux. Pathogenic role of the biliary component

Károly Szentpáli, József Kaszaki, Gábor Erös, László Tiszlavicz, Attila Paszt, György Lázár, Adám Balogh, Mihály Boros

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Our aims were to examine microcirculation during experimental reflux esophagitis in dogs. We compared the effects of microcirculation of the mucosa to 3-hr exposure with acid, mixed acid and bile, we measured the changes in constitutive and inducible nitric oxide synthase activity (cNOS and iNOS). METHODS: The microcirculation of the upper esophagus was investigated by intravital videomicroscopy. The functional capillary density (FCD), relative vessel area (RVA) and red blood cell velocity (RBCV) were measured. Mucosal barrier integrity was examined by vascular and epithelial permeability indices. Myeloperoxidase (MPO) enzyme activity, cNOS, iNOS activities and microscopic damage were examined in biopsies. RESULTS: The vascular permeability index, the RBCV and the RVA increased significantly in the treated groups, the FCD significantly decreased after acid exposure. The MPO and iNOS activities were significantly elevated in all treated groups. The cNOS activity did not change after exposure to acid + bile or acid, but significantly decreased after sole bile treatment. Severe mucosal damage was observed after bile exposure. CONCLUSION: Bile induced characteristic microcirculatory changes during experimental reflux esophagitis. Tissue damage and leukocyte infiltration could be exacerbated by bile-induced cNOS inhibition.

Original languageHungarian
Pages (from-to)61-67
Number of pages7
JournalMagyar sebészet
Volume56
Issue number2
Publication statusPublished - Apr 2003

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ASJC Scopus subject areas

  • Medicine(all)

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