Changes in mental condition, hyperkinesias and biochemical parameters after withdrawal of chronic neuroleptic treatment

A. Perenyi, E. Frecska, G. Bagdy, K. Revai

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12 Citations (Scopus)

Abstract

Neuroleptics were withdrawn abruptly from 14 hospitalized chronic schizophrenics. For 12 weeks the patients were observed from the aspect of psychic change and the development of withdrawal dyskinesia. Serum prolactin level, plasma dopamine-beta-hydroxylase activity, cerebrospinal fluid homovanillic acid and norepinephrine levels were measured on the day prior to withdrawal and on day 14 of the study. Psychic deterioration showed no association with any of the tested biochemical parameters. The decrease in the CSF HVA and NE levels of the patients displaying symptoms of withdrawal dyskinesia was significantly smaller than in those displaying no dyskinesia.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalActa Psychiatrica Scandinavica
Volume72
Issue number5
Publication statusPublished - 1985

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Hyperkinesis
Dyskinesias
Antipsychotic Agents
Dopamine beta-Hydroxylase
Homovanillic Acid
Substance Withdrawal Syndrome
Prolactin
Cerebrospinal Fluid
Norepinephrine
Therapeutics
Serum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Changes in mental condition, hyperkinesias and biochemical parameters after withdrawal of chronic neuroleptic treatment. / Perenyi, A.; Frecska, E.; Bagdy, G.; Revai, K.

In: Acta Psychiatrica Scandinavica, Vol. 72, No. 5, 1985, p. 430-435.

Research output: Contribution to journalArticle

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