Changes in hypothalamic serotonin concentration following manipulations on the gonadotrophic gonadal axis of the constant estrous anovulatory (CEA) rat

L. Kovacs, I. Lengvári, B. Mess

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The effect of pinealectomy or of injection of luteinizing hormone (LH) containing pituitary extract on the serotonin concentration of the hypothalamus was comparatively investigated in female rats with 3 different types of constant estrous anovulatory (CEA) syndrome. CEA syndrome was provoked by frontal hypothalamic deafferentation (FHD), by neonatal androgen treatment (NA) and by exposure of continuous illumination (light induced constant estrous; LCE syndrome). Pinealectomy caused an increase in hypothalamic serotonin concentration in the FHD rat, but failed to increase it in the NA and LCE group. The injection of crude anterior pituitary extract, however, provoked significant elevation of the hypothalamic serotonin concentration equally in all three types of CEA syndrome. Ovariectomy in itself failed to cause any significant change in the serotonin level of the brain. However, pinealectomy or the injection of LH containing pituitary extract proved to be effective also in the ovariectomized CEA animals. It is concluded that the increase in the brain serotonin concentration of CEA rats, observed after pinealectomy or after injection of LH containing crude pituitary extract, is running through a hypothalamo pituitary mechanism rather than through the hormone secreting activity of the ovaries.

Original languageEnglish
Title of host publicationEndokrinologie
Pages45-50
Number of pages6
Volume68
Edition1
Publication statusPublished - 1976

Fingerprint

Serotonin
Luteinizing Hormone
Injections
Androgens
Brain
Ovariectomy
Lighting
Complex Mixtures
Hypothalamus
Ovary
Hormones
Light
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

Cite this

Changes in hypothalamic serotonin concentration following manipulations on the gonadotrophic gonadal axis of the constant estrous anovulatory (CEA) rat. / Kovacs, L.; Lengvári, I.; Mess, B.

Endokrinologie. Vol. 68 1. ed. 1976. p. 45-50.

Research output: Chapter in Book/Report/Conference proceedingChapter

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