A kognitív funkciók változásai cukorbetegségben

Translated title of the contribution: Changes in cognitive function in patients with diabetes mellitus

Barbara Szémán, Géza Nagy, Tímea Varga, Anna Veres-Székely, Mária Sasvári, Dávid Fitala, Adrienn Szöllosi, Rózsa Katonai, Eszter Kotyuk, Anikó Somogyi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Patients with diabetes are approximately 1.5 times more likely to experience cognitive decline than individuals without diabetes mellitus. Most of the data suggest that patients with diabetes have reduced performance in numerous domains of cognitive function. In patients with type 1 diabetes, specific and global deficits involving speed of psychomotor efficiency, information processing, mental flexibility, attention, and visual perception seem to be present, while in patients with type 2 diabetes an increase in memory deficits, a reduction in psychomotor speed, and reduced frontal lobe (executive) functions have been found. The complex pathophysiology of changes in the central nervous system in diabetes has not yet been fully elucidated. It is important to consider the patient's age at the onset of diabetes, the glycemic control status, and the presence of diabetic complications. Neurological consequences of diabetes appear parallel to those observed in the aging brain. Neuroimaging studies highlight several structural cerebral changes, cortical and subcortical atrophy, beside increased leukoaraiosis that occurs in association with diabetes. There is supporting evidence from many hypotheses to explain the pathophysiology of cognitive decline associated with diabetes. The main hypotheses pointing to the potential, implied mechanisms involve hyperglycemia, hypoglycemia, microvascular disease, insulin resistance, hyperinsulinism, hyperphosphorylation of tau protein, and amyloid-β deposition.

Original languageHungarian
Pages (from-to)323-329
Number of pages7
JournalOrvosi hetilap
Volume153
Issue number9
DOIs
Publication statusPublished - Mar 1 2012

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szémán, B., Nagy, G., Varga, T., Veres-Székely, A., Sasvári, M., Fitala, D., Szöllosi, A., Katonai, R., Kotyuk, E., & Somogyi, A. (2012). A kognitív funkciók változásai cukorbetegségben. Orvosi hetilap, 153(9), 323-329. https://doi.org/10.1556/OH.2012.29319