Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death: The Whitehall II study

A. Tabák, M. Kivimäki, E. J. Brunner, G. D. Lowe, M. Jokela, T. N. Akbaraly, A. Singh-Manoux, J. E. Ferrie, D. R. Witte

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Prospective studies show that high C-reactive protein (CRP) levels predict diabetes and cardiovascular disease (CVD), but changes in this marker preceding disease onset are not well characterized. This study describes CRP trajectories prior to type 2 diabetes onset and fatal CVD. Methods: In a prospective cohort of 7350 British civil servants (70% male, mean age 51 years), 558 incident type 2 diabetes cases (75-g oral glucose tolerance test, doctor's diagnosis, or self-report) and 125 certified fatal cardiovascular events were observed during a median follow-up of > 14 years. Trajectories of logarithmically transformed CRP levels prior to incident diabetes or fatal cardiovascular event (cases), or the end of follow-up (controls) were calculated using multilevel modeling. Results: Baseline CRP levels were higher among participants who developed diabetes (median (interquartile range) 1.44 (2.39) vs 0.78 (1.21) mg/l) or fatal CVD (1.49 (2.47) vs 0.84 (1.30) mg/l) compared with controls (both P

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalEuropean Journal of Endocrinology
Volume163
Issue number1
DOIs
Publication statusPublished - Jul 1 2010

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C-Reactive Protein
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Glucose Tolerance Test
Self Report
Prospective Studies

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death : The Whitehall II study. / Tabák, A.; Kivimäki, M.; Brunner, E. J.; Lowe, G. D.; Jokela, M.; Akbaraly, T. N.; Singh-Manoux, A.; Ferrie, J. E.; Witte, D. R.

In: European Journal of Endocrinology, Vol. 163, No. 1, 01.07.2010, p. 89-95.

Research output: Contribution to journalArticle

Tabák, A, Kivimäki, M, Brunner, EJ, Lowe, GD, Jokela, M, Akbaraly, TN, Singh-Manoux, A, Ferrie, JE & Witte, DR 2010, 'Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death: The Whitehall II study', European Journal of Endocrinology, vol. 163, no. 1, pp. 89-95. https://doi.org/10.1530/EJE-10-0277
Tabák, A. ; Kivimäki, M. ; Brunner, E. J. ; Lowe, G. D. ; Jokela, M. ; Akbaraly, T. N. ; Singh-Manoux, A. ; Ferrie, J. E. ; Witte, D. R. / Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death : The Whitehall II study. In: European Journal of Endocrinology. 2010 ; Vol. 163, No. 1. pp. 89-95.
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