Changes in binding to muscarinic and nicotinic cholinergic receptors in the chick telencephalon, following passive avoidance learning

Sz Mezey, A. Székely, R. C. Bourne, P. Kabai, A. Csillág

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Changes in nicotinic and muscarinic cholinergic receptors 30 min after one-trial passive avoidance training were studied in day-old chicks (Gallus domesticus), by quantitative receptor autoradiography. [3H]-α-bungarotoxin (α-BgT) and [3H]-quinuclidinyl benzilate (QNB) were used to monitor changes in 15 forebrain regions for nicotinic and muscarinic receptors, respectively. A significant increase occurred bilaterally in the quantity of bound α-BgT in the lobus parolfactorius, while the amount of bound QNB decreased significantly, and bilaterally, in the hippocampus, hyperstriatum ventrale, lobus parolfactorius and posterolateral telencephalon, pars dorsalis. The data support an involvement of cholinergic receptor types in the neural mechanisms underlying passive avoidance learning.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalNeuroscience Letters
Volume270
Issue number2
DOIs
Publication statusPublished - Jul 30 1999

Fingerprint

Quinuclidinyl Benzilate
Avoidance Learning
Telencephalon
Nicotinic Receptors
Cholinergic Receptors
Muscarinic Receptors
Cholinergic Agents
Bungarotoxins
Prosencephalon
Autoradiography
Chickens
Hippocampus

Keywords

  • Acetylcholine receptors
  • Autoradiography
  • Chick brain
  • Hippocampus
  • Hyperstriatum ventrale
  • Lobus parolfactorius
  • Passive avoidance learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "Changes in nicotinic and muscarinic cholinergic receptors 30 min after one-trial passive avoidance training were studied in day-old chicks (Gallus domesticus), by quantitative receptor autoradiography. [3H]-α-bungarotoxin (α-BgT) and [3H]-quinuclidinyl benzilate (QNB) were used to monitor changes in 15 forebrain regions for nicotinic and muscarinic receptors, respectively. A significant increase occurred bilaterally in the quantity of bound α-BgT in the lobus parolfactorius, while the amount of bound QNB decreased significantly, and bilaterally, in the hippocampus, hyperstriatum ventrale, lobus parolfactorius and posterolateral telencephalon, pars dorsalis. The data support an involvement of cholinergic receptor types in the neural mechanisms underlying passive avoidance learning.",
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AU - Mezey, Sz

AU - Székely, A.

AU - Bourne, R. C.

AU - Kabai, P.

AU - Csillág, A.

PY - 1999/7/30

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N2 - Changes in nicotinic and muscarinic cholinergic receptors 30 min after one-trial passive avoidance training were studied in day-old chicks (Gallus domesticus), by quantitative receptor autoradiography. [3H]-α-bungarotoxin (α-BgT) and [3H]-quinuclidinyl benzilate (QNB) were used to monitor changes in 15 forebrain regions for nicotinic and muscarinic receptors, respectively. A significant increase occurred bilaterally in the quantity of bound α-BgT in the lobus parolfactorius, while the amount of bound QNB decreased significantly, and bilaterally, in the hippocampus, hyperstriatum ventrale, lobus parolfactorius and posterolateral telencephalon, pars dorsalis. The data support an involvement of cholinergic receptor types in the neural mechanisms underlying passive avoidance learning.

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