Changes in autorhythmic heart frequency elicited by redox agents

I. Wittmann, Andras Puppi, Matyas Dely

Research output: Contribution to journalArticle

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Abstract

In isolated frog heart it was established that methylene-blue (MB, an oxidizing agent) decreased, while ascorbate (ASC, a reducing agent) increased the frequency of autorhythmic heart contractions. After MB treatment, in parallel with this phenomenon, the extracellular K+ concentration [K+]o showed a slow increase, but following ASC application a slow decrease occured. Since these correlations are in good accordance with the idea that the pacemaking ability of heart, among other properties, depends on the voltage and time-dependent decrease in potassium conductance following the spike, changes in [K+]o might be one mechanism by which oxidizing and reducing agents modulate heart frequencies. On the basis of the effect of insulin (INS) and K-strophantoside (STR) on these modulatory influences, it is presumed that the changes in slow Δ[K+]o transients might result, at least partly, from the effect of redox agents on the active transport system. In light of the increase in passive K+ fluxes after oxidant treatment and the decrease in this parameter following reductant treatment an effect of redox agents on the characteristics of the K+-channel is also postulated.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalChemico-Biological Interactions
Volume63
Issue number2
DOIs
Publication statusPublished - 1987

Fingerprint

Oxidation-Reduction
Reducing Agents
Oxidants
Potassium Chloride
Active Biological Transport
Methylene Blue
Anura
Potassium
Insulin
Fluxes
Electric potential

Keywords

  • Extracellular K-concentration
  • Heart frequency
  • Insulin
  • K-strophantoside
  • Tissue redox state

ASJC Scopus subject areas

  • Toxicology

Cite this

Changes in autorhythmic heart frequency elicited by redox agents. / Wittmann, I.; Puppi, Andras; Dely, Matyas.

In: Chemico-Biological Interactions, Vol. 63, No. 2, 1987, p. 115-125.

Research output: Contribution to journalArticle

Wittmann, I. ; Puppi, Andras ; Dely, Matyas. / Changes in autorhythmic heart frequency elicited by redox agents. In: Chemico-Biological Interactions. 1987 ; Vol. 63, No. 2. pp. 115-125.
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