Changes in apoptotic and mitotic activity in rectal carcinoma after short-term cytostatic therapy as possible predictive factors

E. Farczádi, J. Szántó, I. Kaszás, I. Benyó, Zs Bodnár, J. Szlobodnyik, B. Szende

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fifteen patients with rectal adenocarcinoma were endoscopically biopsied and given short-term [5 fluorouracil (5FU) (600 mg/m2) and Ca- Folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumor was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumor tissue before and after the short-term chemotherapy. The patients were treated thereafter with long-term, intermittent 5 FU administration and followed up clinically for 413 months. Three patients showed progression of the disease, twelve improved or showed no tumor progression. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumor tissue of responder cases. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be additional predictive factor in rectal adenocarcinoma.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalNeoplasma
Volume46
Issue number4
Publication statusPublished - Jan 1 1999

Keywords

  • Apoptosis
  • Cytostatic therapy
  • Mitotic activity
  • Rectal adenocarcinoma

ASJC Scopus subject areas

  • Cancer Research

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