INTRODUCTION - The surgical treatment of colorectal carcinomas is more and more supplemented with chemo- and radiotherapy. Histological studies were carried out in order to assess the effectiveness of short-term chemotherapy. PATIENTS AND METHODS - Fifteen patients with adenocarcinoma of the rectum were endoscopically biopsied and given short-term [5-fluorouracil (5-FU) (600 mg/m2) and Ca-folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumour was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumour tissue before and after the short term chemotherapy. The patients were treated thereafter with long-term, intermittent 5-FU administration and followed up clinically for 4- 13 months. RESULTS - Three patients showed progression of the disease, twelve improved or showed no progression of the tumour. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumour tissue of the responders. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. CONCLUSION - These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be an additional predictive factors in adenocarcinoma of the rectum.
|Number of pages||5|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Sep 2 1999|
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