Az apoptozis- es mitozis-aktivitas valtozasa mint lehetseges prediktiv faktor, rectumcarcinomaban szenvedo betegek eseteben, rovid ideig adott citosztatikus kezeles utan

Translated title of the contribution: Changes in apoptotic and mitotic activity as possible predictive factors in rectal carcinoma after short-term cytostatic therapy

E. Farczadi, J. Szántó, I. Kaszas, I. Benyo, Z. Bodnar, J. Szlobodnyik, B. Szende

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - The surgical treatment of colorectal carcinomas is more and more supplemented with chemo- and radiotherapy. Histological studies were carried out in order to assess the effectiveness of short-term chemotherapy. PATIENTS AND METHODS - Fifteen patients with adenocarcinoma of the rectum were endoscopically biopsied and given short-term [5-fluorouracil (5-FU) (600 mg/m2) and Ca-folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumour was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumour tissue before and after the short term chemotherapy. The patients were treated thereafter with long-term, intermittent 5-FU administration and followed up clinically for 4- 13 months. RESULTS - Three patients showed progression of the disease, twelve improved or showed no progression of the tumour. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumour tissue of the responders. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. CONCLUSION - These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be an additional predictive factors in adenocarcinoma of the rectum.

Original languageHungarian
Pages (from-to)546-550
Number of pages5
JournalLege Artis Medicinae
Volume9
Issue number7-8
Publication statusPublished - 1999

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Cytostatic Agents
Carcinoma
Mitotic Index
Rectum
Drug Therapy
Fluorouracil
Neoplasms
Adenocarcinoma
Therapeutics
Disease Progression
Colorectal Neoplasms
Radiotherapy
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

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Az apoptozis- es mitozis-aktivitas valtozasa mint lehetseges prediktiv faktor, rectumcarcinomaban szenvedo betegek eseteben, rovid ideig adott citosztatikus kezeles utan. / Farczadi, E.; Szántó, J.; Kaszas, I.; Benyo, I.; Bodnar, Z.; Szlobodnyik, J.; Szende, B.

In: Lege Artis Medicinae, Vol. 9, No. 7-8, 1999, p. 546-550.

Research output: Contribution to journalArticle

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title = "Az apoptozis- es mitozis-aktivitas valtozasa mint lehetseges prediktiv faktor, rectumcarcinomaban szenvedo betegek eseteben, rovid ideig adott citosztatikus kezeles utan",
abstract = "INTRODUCTION - The surgical treatment of colorectal carcinomas is more and more supplemented with chemo- and radiotherapy. Histological studies were carried out in order to assess the effectiveness of short-term chemotherapy. PATIENTS AND METHODS - Fifteen patients with adenocarcinoma of the rectum were endoscopically biopsied and given short-term [5-fluorouracil (5-FU) (600 mg/m2) and Ca-folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumour was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumour tissue before and after the short term chemotherapy. The patients were treated thereafter with long-term, intermittent 5-FU administration and followed up clinically for 4- 13 months. RESULTS - Three patients showed progression of the disease, twelve improved or showed no progression of the tumour. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumour tissue of the responders. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. CONCLUSION - These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be an additional predictive factors in adenocarcinoma of the rectum.",
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T1 - Az apoptozis- es mitozis-aktivitas valtozasa mint lehetseges prediktiv faktor, rectumcarcinomaban szenvedo betegek eseteben, rovid ideig adott citosztatikus kezeles utan

AU - Farczadi, E.

AU - Szántó, J.

AU - Kaszas, I.

AU - Benyo, I.

AU - Bodnar, Z.

AU - Szlobodnyik, J.

AU - Szende, B.

PY - 1999

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N2 - INTRODUCTION - The surgical treatment of colorectal carcinomas is more and more supplemented with chemo- and radiotherapy. Histological studies were carried out in order to assess the effectiveness of short-term chemotherapy. PATIENTS AND METHODS - Fifteen patients with adenocarcinoma of the rectum were endoscopically biopsied and given short-term [5-fluorouracil (5-FU) (600 mg/m2) and Ca-folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumour was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumour tissue before and after the short term chemotherapy. The patients were treated thereafter with long-term, intermittent 5-FU administration and followed up clinically for 4- 13 months. RESULTS - Three patients showed progression of the disease, twelve improved or showed no progression of the tumour. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumour tissue of the responders. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. CONCLUSION - These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be an additional predictive factors in adenocarcinoma of the rectum.

AB - INTRODUCTION - The surgical treatment of colorectal carcinomas is more and more supplemented with chemo- and radiotherapy. Histological studies were carried out in order to assess the effectiveness of short-term chemotherapy. PATIENTS AND METHODS - Fifteen patients with adenocarcinoma of the rectum were endoscopically biopsied and given short-term [5-fluorouracil (5-FU) (600 mg/m2) and Ca-folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumour was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumour tissue before and after the short term chemotherapy. The patients were treated thereafter with long-term, intermittent 5-FU administration and followed up clinically for 4- 13 months. RESULTS - Three patients showed progression of the disease, twelve improved or showed no progression of the tumour. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumour tissue of the responders. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. CONCLUSION - These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be an additional predictive factors in adenocarcinoma of the rectum.

KW - Apoptotic index

KW - Cytostatic therapy

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