Changes in albuminuria and subsequent risk of incident kidney disease

Keiichi Sumida, M. Molnár, Praveen K. Potukuchi, Koshy George, Fridtjof Thomas, Jun Ling Lu, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and objectives Albuminuria is a robust predictor of CKD progression. However, little is known about the associations of changes in albuminuria with the risk of kidney events outside the settings of clinical trials. Design, setting, participants, & measurements In a nationwide cohort of 56,946 United States veterans with an eGFR≥60 ml/min per 1.73 m2, we examined the associations of 1-year fold changes in albuminuria with subsequent incident CKD (>25% decrease in eGFR reaching <60 ml/min per 1.73 m2) and rapid eGFR decline (eGFR slope <-5 ml/min per 1.73 m2 per year) assessed using Cox models and logistic regression, respectively, with adjustment for confounders. Results The mean age was 64 (SD, 10) years old; 97% were men, and91% were diabetic. There was a nearly linear association between 1-year fold changes in albuminuria and incident CKD. The multivariable-adjusted hazard ratios (95% confidence intervals) of incident CKD associated with more than twofold decrease, 1.25- to twofold decrease, 1.25- to twofold increase, and more than twofold increase (versus <1.25-fold decrease to <1.25-fold increase) in albuminuria were 0.82 (95% confidence interval, 0.77 to 0.89), 0.93 (95% confidence interval, 0.86 to 1.00), 1.12 (95% confidence interval, 1.05 to 1.20), and 1.29 (95% confidence interval, 1.21 to 1.38), respectively. Qualitatively similar associations were present for rapid eGFR decline (adjusted odds ratios; 95% confidence intervals for corresponding albuminuria changes: adjusted odds ratio, 0.86; 95% confidence interval, 0.78 to 0.94; adjusted odds ratio, 0.98; 95% confidence interval, 0.89 to 1.07; adjusted odds ratio, 1.18; 95% confidence interval, 1.08 to 1.29; and adjusted odds ratio, 1.67; 95% confidence interval, 1.54 and 1.81, respectively). Conclusions Relative changes in albuminuria over a 1-year interval were linearly associated with subsequent risk of kidney outcomes. Additional studies are warranted to elucidate the underlying mechanisms of the observed associations and test whether active interventions to lower elevated albuminuria can improve kidney outcomes.

Original languageEnglish
Pages (from-to)1941-1949
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 7 2017

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Albuminuria
Kidney Diseases
Confidence Intervals
Odds Ratio
Kidney
Veterans
Proportional Hazards Models
Logistic Models
Clinical Trials

Keywords

  • Albuminuria
  • Chronic kidney disease
  • Diabetes mellitus
  • Glomerular filtration rate
  • Kidney
  • Logistic models
  • Microalbuminuria
  • Odds ratio
  • Proportional hazards models
  • Renal insufficiency, Chronic
  • Veterans

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Sumida, K., Molnár, M., Potukuchi, P. K., George, K., Thomas, F., Lu, J. L., ... Kovesdy, C. P. (2017). Changes in albuminuria and subsequent risk of incident kidney disease. Clinical Journal of the American Society of Nephrology, 12(12), 1941-1949. https://doi.org/10.2215/CJN.02720317

Changes in albuminuria and subsequent risk of incident kidney disease. / Sumida, Keiichi; Molnár, M.; Potukuchi, Praveen K.; George, Koshy; Thomas, Fridtjof; Lu, Jun Ling; Yamagata, Kunihiro; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba P.

In: Clinical Journal of the American Society of Nephrology, Vol. 12, No. 12, 07.12.2017, p. 1941-1949.

Research output: Contribution to journalArticle

Sumida, K, Molnár, M, Potukuchi, PK, George, K, Thomas, F, Lu, JL, Yamagata, K, Kalantar-Zadeh, K & Kovesdy, CP 2017, 'Changes in albuminuria and subsequent risk of incident kidney disease', Clinical Journal of the American Society of Nephrology, vol. 12, no. 12, pp. 1941-1949. https://doi.org/10.2215/CJN.02720317
Sumida, Keiichi ; Molnár, M. ; Potukuchi, Praveen K. ; George, Koshy ; Thomas, Fridtjof ; Lu, Jun Ling ; Yamagata, Kunihiro ; Kalantar-Zadeh, Kamyar ; Kovesdy, Csaba P. / Changes in albuminuria and subsequent risk of incident kidney disease. In: Clinical Journal of the American Society of Nephrology. 2017 ; Vol. 12, No. 12. pp. 1941-1949.
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abstract = "Background and objectives Albuminuria is a robust predictor of CKD progression. However, little is known about the associations of changes in albuminuria with the risk of kidney events outside the settings of clinical trials. Design, setting, participants, & measurements In a nationwide cohort of 56,946 United States veterans with an eGFR≥60 ml/min per 1.73 m2, we examined the associations of 1-year fold changes in albuminuria with subsequent incident CKD (>25{\%} decrease in eGFR reaching <60 ml/min per 1.73 m2) and rapid eGFR decline (eGFR slope <-5 ml/min per 1.73 m2 per year) assessed using Cox models and logistic regression, respectively, with adjustment for confounders. Results The mean age was 64 (SD, 10) years old; 97{\%} were men, and91{\%} were diabetic. There was a nearly linear association between 1-year fold changes in albuminuria and incident CKD. The multivariable-adjusted hazard ratios (95{\%} confidence intervals) of incident CKD associated with more than twofold decrease, 1.25- to twofold decrease, 1.25- to twofold increase, and more than twofold increase (versus <1.25-fold decrease to <1.25-fold increase) in albuminuria were 0.82 (95{\%} confidence interval, 0.77 to 0.89), 0.93 (95{\%} confidence interval, 0.86 to 1.00), 1.12 (95{\%} confidence interval, 1.05 to 1.20), and 1.29 (95{\%} confidence interval, 1.21 to 1.38), respectively. Qualitatively similar associations were present for rapid eGFR decline (adjusted odds ratios; 95{\%} confidence intervals for corresponding albuminuria changes: adjusted odds ratio, 0.86; 95{\%} confidence interval, 0.78 to 0.94; adjusted odds ratio, 0.98; 95{\%} confidence interval, 0.89 to 1.07; adjusted odds ratio, 1.18; 95{\%} confidence interval, 1.08 to 1.29; and adjusted odds ratio, 1.67; 95{\%} confidence interval, 1.54 and 1.81, respectively). Conclusions Relative changes in albuminuria over a 1-year interval were linearly associated with subsequent risk of kidney outcomes. Additional studies are warranted to elucidate the underlying mechanisms of the observed associations and test whether active interventions to lower elevated albuminuria can improve kidney outcomes.",
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AU - Potukuchi, Praveen K.

AU - George, Koshy

AU - Thomas, Fridtjof

AU - Lu, Jun Ling

AU - Yamagata, Kunihiro

AU - Kalantar-Zadeh, Kamyar

AU - Kovesdy, Csaba P.

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N2 - Background and objectives Albuminuria is a robust predictor of CKD progression. However, little is known about the associations of changes in albuminuria with the risk of kidney events outside the settings of clinical trials. Design, setting, participants, & measurements In a nationwide cohort of 56,946 United States veterans with an eGFR≥60 ml/min per 1.73 m2, we examined the associations of 1-year fold changes in albuminuria with subsequent incident CKD (>25% decrease in eGFR reaching <60 ml/min per 1.73 m2) and rapid eGFR decline (eGFR slope <-5 ml/min per 1.73 m2 per year) assessed using Cox models and logistic regression, respectively, with adjustment for confounders. Results The mean age was 64 (SD, 10) years old; 97% were men, and91% were diabetic. There was a nearly linear association between 1-year fold changes in albuminuria and incident CKD. The multivariable-adjusted hazard ratios (95% confidence intervals) of incident CKD associated with more than twofold decrease, 1.25- to twofold decrease, 1.25- to twofold increase, and more than twofold increase (versus <1.25-fold decrease to <1.25-fold increase) in albuminuria were 0.82 (95% confidence interval, 0.77 to 0.89), 0.93 (95% confidence interval, 0.86 to 1.00), 1.12 (95% confidence interval, 1.05 to 1.20), and 1.29 (95% confidence interval, 1.21 to 1.38), respectively. Qualitatively similar associations were present for rapid eGFR decline (adjusted odds ratios; 95% confidence intervals for corresponding albuminuria changes: adjusted odds ratio, 0.86; 95% confidence interval, 0.78 to 0.94; adjusted odds ratio, 0.98; 95% confidence interval, 0.89 to 1.07; adjusted odds ratio, 1.18; 95% confidence interval, 1.08 to 1.29; and adjusted odds ratio, 1.67; 95% confidence interval, 1.54 and 1.81, respectively). Conclusions Relative changes in albuminuria over a 1-year interval were linearly associated with subsequent risk of kidney outcomes. Additional studies are warranted to elucidate the underlying mechanisms of the observed associations and test whether active interventions to lower elevated albuminuria can improve kidney outcomes.

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KW - Renal insufficiency, Chronic

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