Az immunválasz változása (NK, K sejt) nogyógyászati rosszindulatú daganatos betegek kezelése kapcsán. A neoadjuváns kemoterápia hatása III

Translated title of the contribution: Change of the immune response (NK, K cell) after treatment of patients with malignant gynecologic cervix cancer. Effect of the neoadjuvant chemotherapy III

F. Bánhidy, Siklós Pál, L. Ungár, L. Pálfalvi, Szántó István

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study was to investigate whether there is a change in Natural Killer (NK) and Killer (K) cell activity after a treatment with neoadjuvant chemotherapy on patients with carcinoma of the uterina cervix? Is there an immunologic explanation for this? Do the NK and K cells behave similarly or not? Study design: 30 patients with cervical malignancy took part in our study. They were treated with neoadjuvant chemotherapy. We examined the NK cell activity in relation to target cells originating from the K-562 myeloid leukemia cell line. We examined the antibody-dependent cellular cytotoxicity (ADCC) of the K cells m relation to "O" Rh+(D) red blood cells. We used the cytotoxic enzyme kinetics model to determine the maximum NK and K cell activity. We used the BMDP Mann - Whitney, Kruskal - Wallis trials in our mathematical analysis. Results: Cytotoxic activity of NK and K cells in patients with cervical malignancies without treatment with neoadjuvant chemotherapy was found non-significant influences. Conclusion: The neoadjuvant chemotherapy itself of both cell types did not cause a decrease or increase in NK and K cell activity. Both cells types (NK and K) behave similarly.

Original languageHungarian
Pages (from-to)153-155
Number of pages3
JournalMagyar Onkologia
Volume41
Issue number3
Publication statusPublished - 1997

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Uterine Cervical Neoplasms
Natural Killer Cells
Drug Therapy
Neoadjuvant Therapy
Therapeutics
Myeloid Leukemia
Myeloid Cells
Cervix Uteri
Neoplasms
Erythrocytes
Carcinoma
Cell Line
Antibodies
Enzymes

ASJC Scopus subject areas

  • Oncology

Cite this

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title = "Az immunv{\'a}lasz v{\'a}ltoz{\'a}sa (NK, K sejt) nogy{\'o}gy{\'a}szati rosszindulat{\'u} daganatos betegek kezel{\'e}se kapcs{\'a}n. A neoadjuv{\'a}ns kemoter{\'a}pia hat{\'a}sa III",
abstract = "Objective: The aim of the study was to investigate whether there is a change in Natural Killer (NK) and Killer (K) cell activity after a treatment with neoadjuvant chemotherapy on patients with carcinoma of the uterina cervix? Is there an immunologic explanation for this? Do the NK and K cells behave similarly or not? Study design: 30 patients with cervical malignancy took part in our study. They were treated with neoadjuvant chemotherapy. We examined the NK cell activity in relation to target cells originating from the K-562 myeloid leukemia cell line. We examined the antibody-dependent cellular cytotoxicity (ADCC) of the K cells m relation to {"}O{"} Rh+(D) red blood cells. We used the cytotoxic enzyme kinetics model to determine the maximum NK and K cell activity. We used the BMDP Mann - Whitney, Kruskal - Wallis trials in our mathematical analysis. Results: Cytotoxic activity of NK and K cells in patients with cervical malignancies without treatment with neoadjuvant chemotherapy was found non-significant influences. Conclusion: The neoadjuvant chemotherapy itself of both cell types did not cause a decrease or increase in NK and K cell activity. Both cells types (NK and K) behave similarly.",
author = "F. B{\'a}nhidy and Sikl{\'o}s P{\'a}l and L. Ung{\'a}r and L. P{\'a}lfalvi and Sz{\'a}nt{\'o} Istv{\'a}n",
year = "1997",
language = "Hungarian",
volume = "41",
pages = "153--155",
journal = "Magyar Onkologia",
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TY - JOUR

T1 - Az immunválasz változása (NK, K sejt) nogyógyászati rosszindulatú daganatos betegek kezelése kapcsán. A neoadjuváns kemoterápia hatása III

AU - Bánhidy, F.

AU - Pál, Siklós

AU - Ungár, L.

AU - Pálfalvi, L.

AU - István, Szántó

PY - 1997

Y1 - 1997

N2 - Objective: The aim of the study was to investigate whether there is a change in Natural Killer (NK) and Killer (K) cell activity after a treatment with neoadjuvant chemotherapy on patients with carcinoma of the uterina cervix? Is there an immunologic explanation for this? Do the NK and K cells behave similarly or not? Study design: 30 patients with cervical malignancy took part in our study. They were treated with neoadjuvant chemotherapy. We examined the NK cell activity in relation to target cells originating from the K-562 myeloid leukemia cell line. We examined the antibody-dependent cellular cytotoxicity (ADCC) of the K cells m relation to "O" Rh+(D) red blood cells. We used the cytotoxic enzyme kinetics model to determine the maximum NK and K cell activity. We used the BMDP Mann - Whitney, Kruskal - Wallis trials in our mathematical analysis. Results: Cytotoxic activity of NK and K cells in patients with cervical malignancies without treatment with neoadjuvant chemotherapy was found non-significant influences. Conclusion: The neoadjuvant chemotherapy itself of both cell types did not cause a decrease or increase in NK and K cell activity. Both cells types (NK and K) behave similarly.

AB - Objective: The aim of the study was to investigate whether there is a change in Natural Killer (NK) and Killer (K) cell activity after a treatment with neoadjuvant chemotherapy on patients with carcinoma of the uterina cervix? Is there an immunologic explanation for this? Do the NK and K cells behave similarly or not? Study design: 30 patients with cervical malignancy took part in our study. They were treated with neoadjuvant chemotherapy. We examined the NK cell activity in relation to target cells originating from the K-562 myeloid leukemia cell line. We examined the antibody-dependent cellular cytotoxicity (ADCC) of the K cells m relation to "O" Rh+(D) red blood cells. We used the cytotoxic enzyme kinetics model to determine the maximum NK and K cell activity. We used the BMDP Mann - Whitney, Kruskal - Wallis trials in our mathematical analysis. Results: Cytotoxic activity of NK and K cells in patients with cervical malignancies without treatment with neoadjuvant chemotherapy was found non-significant influences. Conclusion: The neoadjuvant chemotherapy itself of both cell types did not cause a decrease or increase in NK and K cell activity. Both cells types (NK and K) behave similarly.

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