Objective: The aim of the study was to investigate whether there is a change in Natural Killer (NK) and Killer (K) cell activity after a treatment with neoadjuvant chemotherapy on patients with carcinoma of the uterina cervix? Is there an immunologic explanation for this? Do the NK and K cells behave similarly or not? Study design: 30 patients with cervical malignancy took part in our study. They were treated with neoadjuvant chemotherapy. We examined the NK cell activity in relation to target cells originating from the K-562 myeloid leukemia cell line. We examined the antibody-dependent cellular cytotoxicity (ADCC) of the K cells m relation to "O" Rh+(D) red blood cells. We used the cytotoxic enzyme kinetics model to determine the maximum NK and K cell activity. We used the BMDP Mann - Whitney, Kruskal - Wallis trials in our mathematical analysis. Results: Cytotoxic activity of NK and K cells in patients with cervical malignancies without treatment with neoadjuvant chemotherapy was found non-significant influences. Conclusion: The neoadjuvant chemotherapy itself of both cell types did not cause a decrease or increase in NK and K cell activity. Both cells types (NK and K) behave similarly.
|Number of pages||3|
|Publication status||Published - Dec 1 1997|
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