Change of composition of human lens proteins in the course of opacity formation of senile cataracts

A. Facsko, I. Édes, I. Sziklai

Research output: Contribution to journalArticle

Abstract

The composition of lens proteins was studied in different stages of senile cataracts. According to the results in the course of opacity formation, the solubility of proteins is declining and in different fractions polypeptide chains with higher molecular weight are slowly augmenting. In the soluble fraction subgroups of 50,000 to 200,000 Daltons, in the urea soluble fraction the amount of polypeptide chains of 200,000 Daltons is increasing. In this latter subgroup (in the yellow protein fraction), protein with higher molecular weight than 400,000 Daltons could also be detected. It is suggested that proteins with a high molecular weight are arising by cross-bonds of proteins with lower molecular weight.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalSzemeszet Ophthalmologica Hungarica
Volume117
Issue number2
Publication statusPublished - 1980

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Crystallins
Cataract
Molecular Weight
Proteins
Peptides
Solubility
Urea

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Change of composition of human lens proteins in the course of opacity formation of senile cataracts. / Facsko, A.; Édes, I.; Sziklai, I.

In: Szemeszet Ophthalmologica Hungarica, Vol. 117, No. 2, 1980, p. 79-83.

Research output: Contribution to journalArticle

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