Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study

Katalin T. Kovacs, Sudhakar Reddy Kalluri, Antonio Boza-Serrano, Tomas Deierborg, Tunde Csepany, Magdolna Simo, Laszlo Rokusz, A. Miseta, Nicolas Alcaraz, L. Czirják, T. Berki, Tihamer Molnar, Bernhard Hemmer, Zsolt Illes

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6 Citations (Scopus)

Abstract

Background: Neuromyelitis optica (NMO)-systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies. Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute. Methods: In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission. Results: AQP4-IgG1 was present 1-2-5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-γ,interferon-gamma-induced CCL10/IP-10 and CCL17/TARC (p

Original languageEnglish
Pages (from-to)1192-1201
Number of pages10
JournalMultiple Sclerosis
Volume22
Issue number9
DOIs
Publication statusPublished - Aug 1 2016

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Keywords

  • AQP4
  • IL-17
  • IP-10
  • myelin oligodendrocyte glycoprotein
  • SLE
  • Th1
  • Th17

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Kovacs, K. T., Kalluri, S. R., Boza-Serrano, A., Deierborg, T., Csepany, T., Simo, M., Rokusz, L., Miseta, A., Alcaraz, N., Czirják, L., Berki, T., Molnar, T., Hemmer, B., & Illes, Z. (2016). Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study. Multiple Sclerosis, 22(9), 1192-1201. https://doi.org/10.1177/1352458515613165