CGRP antagonists and antibodies for the treatment of migraine

László Vécsei, Délia Szok, Anett Csáti, János Tajti

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Introduction: Migraine is a highly devastating neurovascular disorder that affects up to 16% of the population worldwide. In spite of intensive research, its origin remains enigmatic with no therapeutic option appropriate for all migraine patients. One of the leading hypotheses is related to the function of the calcitonin gene-related peptide (CGRP). Regardless, the pharmaceutical options currently applied for the acute and prophylactic treatment of migraine are not appropriate for all migraine patients.

Areas covered: This article is based on a literature review using the PubMed database and highlights the CGRP theory of the pathomechanism of migraine.

Expert opinion: Since migraine is a CGRP-related disorder, it appeared obvious to develop CGRP receptor antagonists that exert high efficacy, both intravenously and orally. Unfortunately, the frequent use of these antagonists results in an elevated liver transaminase level. In an attempt to bypass these harmful side effects, efforts should be made to modify these pharmacons. The use of fully humanized monoclonal antibodies (mAbs) that target CGRP and its receptors may also be possible. However, while Phase I and II clinical trials are promising, a long-term follow-up of these therapies is still needed.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalExpert Opinion on Investigational Drugs
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Anti-calcitonin gene-related peptide mAbs
  • Anti-calcitonin gene-related peptide receptor mAbs
  • Calcitonin gene-related peptide
  • Calcitonin gene-related peptide receptor antagonists
  • Calcitonin gene-related peptide receptors
  • Migraine treatment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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