Certain rheologycal behaviour of paracetamol solid dispersion powders

Lj M. Tasic, K. Pintye-Hódi

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Abstract

Paracetamol powder (PAR) has poor compressibility, high cohesivity and is difficult to compress. We have prepared dispersions of PAR and 3-cyclodextrin (β-CD) in physical mixture form, kneaded solid dispersion and spray dried solid dispersion (the ratio 1:1 w/w), and spray dried solid dispersion of PAR-Ethocel-Macogol 6000 (95:2:3), as well. The Theological characteristics of this dispersions were observed. The crystalline structure, size and shape of PAR dispersion powders differed from PAR alone. Consequently, they showed improvement in packing density; reductions in cohesivity (Kawakita's cohesivity constant was the lowest with kneaded solid dispersion PAR-β-CD); good flowability and angle of repose (especially with kneded solid dispersion PAR-β-CD). We also examined the rheological behaviour of tablet formulations prepared from those dispersions and found some correlation between the weight variation of tablets and the mixture flow properties.

Original languageEnglish
Pages (from-to)401-408
Number of pages8
JournalBollettino Chimico Farmaceutico
Volume135
Issue number7
Publication statusPublished - Jan 1 1996

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Keywords

  • Paracetamol
  • Powder rheology
  • Solid dispersion
  • β-cyclodextrin

ASJC Scopus subject areas

  • Molecular Medicine

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