Cerebrovascularis reaktivitás nem inzulindependens diabetes mellitusban (elözetes eredmények).

Translated title of the contribution: Cerebrovascular reactivity in non-insulin dependent diabetes mellitus (preliminary results)

B. Fülesdi, M. Limburg, C. Molnár, M. Káplár, D. Bereczki, G. Neuwirth, L. Csiba

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

AIMS: Previously numerous investigators reported about impairment of cerebrovascular reserve capacity in Type I, diabetes mellitus. However, no similar data are available about patients suffering from Type II diabetes. The goal of the study was to assess cerebrovascular reserve in Type II diabetic patients. PATIENTS AND METHODS: 14 NIDDM patients and 20 healthy controls were studied. Middle cerebral artery mean blood flow velocity was measured at rest and during 20 minutes after i.v. administration of 1 g. acetazolamide. Velocities measured after acetazolamide were compared to resting values and were expressed as the percent increase of the mean velocity. Data obtained in diabetics and healthy persons were compared using Student's t-test. The correlation between age of the patients, diabetes duration, actual blood glucose-, insulin-, glycosylated hemoglobin-, urine microalbumin concentrations and resting blood flow velocity and cerebrovascular reserve capacity was assessed using linear regression analysis. RESULTS: Resting cerebral blood flow velocities, cerebrovascular reactivity and reserve capacity did not differ from that of healthy controls. No correlation has been found between obtained laboratory parameters and resting cerebral blood flow velocities and cerebrovascular reserve capacity. CONCLUSIONS: Vasodilatory ability of the cerebral arterioles in NIDDM-patients did not differ from that of healthy control persons. Further studies are needed to find out an accurate screening method for detection of cerebral microangiopathic changes in Type II diabetes mellitus.

Translated title of the contributionCerebrovascular reactivity in non-insulin dependent diabetes mellitus (preliminary results)
Original languageHungarian
Pages (from-to)1789-1792
Number of pages4
JournalOrvosi hetilap
Volume139
Issue number30
Publication statusPublished - Jul 26 1998

ASJC Scopus subject areas

  • Medicine(all)

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