Cerebrovascular reactivity in hypertensive patients: A transcranial Doppler study

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Abstract

Purpose. We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity in patients with hypertension and the hemodynamic consequences of hypertension. Methods. The study group comprised 25 patients with chronic severe hypertension and 25 age- and sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by transcranial Doppler recording of the blood flow velocity in both middle cerebral arteries before and 5, 10, 15, and 20 minutes after intravenous injection of 1 g of acetazolamide (Diamox). Blood pressure, blood gases, and other blood parameters were also measured before and after acetazolamide injection. The sizes of the left atrium, left ventricle, and aortic root were measured by echocardiography and correlated with the vasoreactivity after acetazolamide injection. Results. After acetazolamide injection, no significant changes in blood pressure were observed in either group. The mean blood flow velocity in the middle cerebral arteries of hypertensive patients (60.8 ± 2.6 cm/sec) was not significantly different from that of controls (68.8 ± 1.9 cm/sec) before acetazolamide injection. Ten minutes after acetazolamide injection, the percentage change in blood flow velocity was significantly lower in the hypertensive group (36.2 ± 4.5%) than in the controls (52.6 ± 3.7%). A significant negative correlation (p <0.05) between decreased vasoreactivity and increased size of the left atrium and aortic root was observed. Conclusions. Vasoreactivity decreases in hypertensive patients without neurologic deficits or computed tomography abnormalities. Enlargement of the left atrium correlates well with the severity of the impairment in vasoreactivity. Transcranial Doppler sonography can be a sensitive tool in the investigation of vascular impairment caused by hypertension and in the follow-up of hypertensive patients.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Clinical Ultrasound
Volume25
Issue number7
DOIs
Publication statusPublished - Sep 1997

Fingerprint

acetazolamide
Acetazolamide
hypertension
reactivity
injection
blood flow
Blood Flow Velocity
Injections
Heart Atria
blood pressure
Hypertension
flow velocity
Doppler Transcranial Ultrasonography
impairment
arteries
Middle Cerebral Artery
blood
echocardiography
hemodynamics
Blood Pressure

Keywords

  • Acetazolamide
  • Cerebrovascular vasomotor reactivity
  • Hypertension
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

@article{fdacd83e565743da97cd53f92ab8c4b1,
title = "Cerebrovascular reactivity in hypertensive patients: A transcranial Doppler study",
abstract = "Purpose. We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity in patients with hypertension and the hemodynamic consequences of hypertension. Methods. The study group comprised 25 patients with chronic severe hypertension and 25 age- and sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by transcranial Doppler recording of the blood flow velocity in both middle cerebral arteries before and 5, 10, 15, and 20 minutes after intravenous injection of 1 g of acetazolamide (Diamox). Blood pressure, blood gases, and other blood parameters were also measured before and after acetazolamide injection. The sizes of the left atrium, left ventricle, and aortic root were measured by echocardiography and correlated with the vasoreactivity after acetazolamide injection. Results. After acetazolamide injection, no significant changes in blood pressure were observed in either group. The mean blood flow velocity in the middle cerebral arteries of hypertensive patients (60.8 ± 2.6 cm/sec) was not significantly different from that of controls (68.8 ± 1.9 cm/sec) before acetazolamide injection. Ten minutes after acetazolamide injection, the percentage change in blood flow velocity was significantly lower in the hypertensive group (36.2 ± 4.5{\%}) than in the controls (52.6 ± 3.7{\%}). A significant negative correlation (p <0.05) between decreased vasoreactivity and increased size of the left atrium and aortic root was observed. Conclusions. Vasoreactivity decreases in hypertensive patients without neurologic deficits or computed tomography abnormalities. Enlargement of the left atrium correlates well with the severity of the impairment in vasoreactivity. Transcranial Doppler sonography can be a sensitive tool in the investigation of vascular impairment caused by hypertension and in the follow-up of hypertensive patients.",
keywords = "Acetazolamide, Cerebrovascular vasomotor reactivity, Hypertension, Transcranial Doppler sonography",
author = "Andrea Ficzere and A. Valikovics and B. F{\"u}lesdi and A. Juh{\'a}sz and I. Czuriga and L. Csiba",
year = "1997",
month = "9",
doi = "10.1002/(SICI)1097-0096(199709)25:7<383::AID-JCU6>3.0.CO;2-6",
language = "English",
volume = "25",
pages = "383--389",
journal = "Journal of Clinical Ultrasound",
issn = "0091-2751",
publisher = "John Wiley and Sons Inc.",
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}

TY - JOUR

T1 - Cerebrovascular reactivity in hypertensive patients

T2 - A transcranial Doppler study

AU - Ficzere, Andrea

AU - Valikovics, A.

AU - Fülesdi, B.

AU - Juhász, A.

AU - Czuriga, I.

AU - Csiba, L.

PY - 1997/9

Y1 - 1997/9

N2 - Purpose. We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity in patients with hypertension and the hemodynamic consequences of hypertension. Methods. The study group comprised 25 patients with chronic severe hypertension and 25 age- and sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by transcranial Doppler recording of the blood flow velocity in both middle cerebral arteries before and 5, 10, 15, and 20 minutes after intravenous injection of 1 g of acetazolamide (Diamox). Blood pressure, blood gases, and other blood parameters were also measured before and after acetazolamide injection. The sizes of the left atrium, left ventricle, and aortic root were measured by echocardiography and correlated with the vasoreactivity after acetazolamide injection. Results. After acetazolamide injection, no significant changes in blood pressure were observed in either group. The mean blood flow velocity in the middle cerebral arteries of hypertensive patients (60.8 ± 2.6 cm/sec) was not significantly different from that of controls (68.8 ± 1.9 cm/sec) before acetazolamide injection. Ten minutes after acetazolamide injection, the percentage change in blood flow velocity was significantly lower in the hypertensive group (36.2 ± 4.5%) than in the controls (52.6 ± 3.7%). A significant negative correlation (p <0.05) between decreased vasoreactivity and increased size of the left atrium and aortic root was observed. Conclusions. Vasoreactivity decreases in hypertensive patients without neurologic deficits or computed tomography abnormalities. Enlargement of the left atrium correlates well with the severity of the impairment in vasoreactivity. Transcranial Doppler sonography can be a sensitive tool in the investigation of vascular impairment caused by hypertension and in the follow-up of hypertensive patients.

AB - Purpose. We studied the usefulness of transcranial Doppler sonography for assessing changes in vasoreactivity in patients with hypertension and the hemodynamic consequences of hypertension. Methods. The study group comprised 25 patients with chronic severe hypertension and 25 age- and sex-matched healthy subjects. Cerebrovascular reserve capacity was assessed by transcranial Doppler recording of the blood flow velocity in both middle cerebral arteries before and 5, 10, 15, and 20 minutes after intravenous injection of 1 g of acetazolamide (Diamox). Blood pressure, blood gases, and other blood parameters were also measured before and after acetazolamide injection. The sizes of the left atrium, left ventricle, and aortic root were measured by echocardiography and correlated with the vasoreactivity after acetazolamide injection. Results. After acetazolamide injection, no significant changes in blood pressure were observed in either group. The mean blood flow velocity in the middle cerebral arteries of hypertensive patients (60.8 ± 2.6 cm/sec) was not significantly different from that of controls (68.8 ± 1.9 cm/sec) before acetazolamide injection. Ten minutes after acetazolamide injection, the percentage change in blood flow velocity was significantly lower in the hypertensive group (36.2 ± 4.5%) than in the controls (52.6 ± 3.7%). A significant negative correlation (p <0.05) between decreased vasoreactivity and increased size of the left atrium and aortic root was observed. Conclusions. Vasoreactivity decreases in hypertensive patients without neurologic deficits or computed tomography abnormalities. Enlargement of the left atrium correlates well with the severity of the impairment in vasoreactivity. Transcranial Doppler sonography can be a sensitive tool in the investigation of vascular impairment caused by hypertension and in the follow-up of hypertensive patients.

KW - Acetazolamide

KW - Cerebrovascular vasomotor reactivity

KW - Hypertension

KW - Transcranial Doppler sonography

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U2 - 10.1002/(SICI)1097-0096(199709)25:7<383::AID-JCU6>3.0.CO;2-6

DO - 10.1002/(SICI)1097-0096(199709)25:7<383::AID-JCU6>3.0.CO;2-6

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