Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge

Georgios Settakis, D. Páll, Csilla Molnár, D. Bereczki, L. Csiba, B. Fülesdi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background. Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. Methods. From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results. Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion. Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalJournal of Neuroimaging
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 2003

Fingerprint

Breath Holding
Blood Flow Velocity
Hypertension
Morbidity
Population

Keywords

  • Adolescence
  • Arterial hypertension
  • Breath-holding test
  • Cerebrovascular reactivity to CO
  • Target organ damage
  • Transcranial Doppler

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Cerebrovascular reactivity in hypertensive and healthy adolescents : TCD with vasodilatory challenge. / Settakis, Georgios; Páll, D.; Molnár, Csilla; Bereczki, D.; Csiba, L.; Fülesdi, B.

In: Journal of Neuroimaging, Vol. 13, No. 2, 04.2003, p. 106-112.

Research output: Contribution to journalArticle

@article{4acebf92f7e244548585091aaa5f947a,
title = "Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge",
abstract = "Background. Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. Methods. From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results. Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion. Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.",
keywords = "Adolescence, Arterial hypertension, Breath-holding test, Cerebrovascular reactivity to CO, Target organ damage, Transcranial Doppler",
author = "Georgios Settakis and D. P{\'a}ll and Csilla Moln{\'a}r and D. Bereczki and L. Csiba and B. F{\"u}lesdi",
year = "2003",
month = "4",
doi = "10.1177/1051228403251265",
language = "English",
volume = "13",
pages = "106--112",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Cerebrovascular reactivity in hypertensive and healthy adolescents

T2 - TCD with vasodilatory challenge

AU - Settakis, Georgios

AU - Páll, D.

AU - Molnár, Csilla

AU - Bereczki, D.

AU - Csiba, L.

AU - Fülesdi, B.

PY - 2003/4

Y1 - 2003/4

N2 - Background. Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. Methods. From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results. Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion. Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.

AB - Background. Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. Methods. From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results. Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion. Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.

KW - Adolescence

KW - Arterial hypertension

KW - Breath-holding test

KW - Cerebrovascular reactivity to CO

KW - Target organ damage

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=0345074108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345074108&partnerID=8YFLogxK

U2 - 10.1177/1051228403251265

DO - 10.1177/1051228403251265

M3 - Article

C2 - 12722492

AN - SCOPUS:0345074108

VL - 13

SP - 106

EP - 112

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 2

ER -