Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge

Georgios Settakis, Dénes Páll, Csilla Molnár, Dániel Bereczki, László Csiba, Béla Fülesdi

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39 Citations (Scopus)


Background. Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents. Methods. From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding. Results. Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers. Conclusion. Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalJournal of Neuroimaging
Issue number2
Publication statusPublished - Apr 1 2003



  • Adolescence
  • Arterial hypertension
  • Breath-holding test
  • Cerebrovascular reactivity to CO
  • Target organ damage
  • Transcranial Doppler

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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